Method of detecting an antibody in a liquid sample

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S004000, C435S007100, C435S007500, C435S007900, C435S007930, C435S007940, C435S007950, C435S174000, C435S175000, C435S176000, C435S177000, C435S178000, C435S179000, C435S180000, C435S181000, C435S182000, C435S183000, C436S501000, C436S512000, C436S513000, C436S517000, C436S518000, C436S523000, C436S524000, C436S525000, C436S528000, C436S534000, C436S536000, C436S538000, C436S540000, C436S542000, C436S804000, C436S824000, C436S825000, C436S164000, C324S214000

Reexamination Certificate

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06939681

ABSTRACT:
The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of the sample and a ligand in the form of an antigen, an antibody or a hapten, the ligand being directed to the Fab region of the sample antibody, is carried out in the presence of other constituents of the sample to obtain a measurement1,2) determining the content of an antibody in the liquid sample using an immunoassay, wherein the reaction between the antibody of the sample and a ligand in the form of an antigen, an antibody or a hapten, the ligand being directed to the Fab region of the sample antibody, is carried out in the absence of other constituents of the sample to obtain a measurement2,and 3) interrelating measurements1and2to express the interference and using the interference as a parameter for evaluating the immunological status of the subject.

REFERENCES:
patent: 4891313 (1990-01-01), Berger et al.
patent: 6087188 (2000-07-01), Johansen et al.
patent: WO 98/16829 (1998-04-01), None

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