Method of detecting abnormally phosphorylated tau(.tau.)

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 792, 435 795, 436518, G01N 3353

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active

056019858

ABSTRACT:
Antibodies specifically reactive with an abnormally phosphorylated peptide comprising SEQ ID NO: 3 wherein a serine in SEQ ID NO: 3 is abnormally phosphorylated are provided. Methods of detecting abnormally phosphorylated .tau. in a test sample and methods of diagnosing Alzheimer's Disease with these antibodies are also provided.

REFERENCES:
H. C. Chui, Arch. Neurol. (Chicago) 46, 806 (1989).
D. L. Price et al., BioEssays 10, 69 (1989).
D. J. Selkoe, Annu. Rev. Neurosci, 12, 463 (1989).
J. Q. Trojanowski et al, Annu. Rev. Gerontol. Ceriat., 10, 167 (1991).
C. M. Wischik, Curr. Opin. Cell Biol. 1, 115 (1989).
S. G. Greenberg and P. Davies, Proc. Natl. Acad. Sci. U.S.A. 87, 5827 (1990).
M. Geodert et al., ibid, 85, 4051 (1988).
J. Kondo et al., Neuron 1, 827 (1988).
C. M. Wischik et al, Proc. Natl. Acad. Sci. U.S.A. 85, 4506, (1988).
B. L. Wolozin et al., Science 232, 648 (1986).
B. L. Wolozin et al. Proc. Natl. Acad. Sci. U.S.A. 85, 6202 (1988).
H. Ksiezak-Reding et al., J. Biol. Chem. 263, 7943 (1988).
N. Nukina et al., Neurosci. Lett. 87,240 (1988).
H. Ksiezak-Reding et al., J. Neurosci, Res. 25, 420 (1990).
H. Ksiezak-Reding et al., J. Neurosci Res 25:412 (1990).
H. Arai, et al., Proc. Natl. Acad. Sci. U.S.A. 87, 2249 (1990).
M. L. Schmidt. V.M.-Y. Lee J. Q. Trojanowski, Am. J. Pathol. 136, 1069 (1990).
R. A. Stern, L. Otvos. Jr., J. Q. Trojanowski, V.M.-Y. Lee, ibid, 134, 973 (1989).
V.M.-Y. Lee, B. J. Balin, L. Otvos. Jr., J. Q. Trojanowski, unpublished data.
M. Goedert, M. G. Spillantini, M. C. Potier, J. Ulrich, R. A. Crowther, EMBO J. 8, 393 (1989).
M. Goedert, M. G. Spillantini, R. Jakes, D. Rutherford, R. A. Crowther, Neuron 3, 519 (1989).
R. B. Vallee, J. Cell Biol. 92, 435 (1982).
J. Q. Trojanowski, T. Schuck, M. L. Schmidt, V. M.Y-Lee, J. Histochem. Cytochem. 37, 209 (1989).
K. S. Kosik et al., Neuron 1, 816 (1988).
Grundke-Iqbal et al., Proc. Natl. Acad. Sci. U.S.A. 83, 4913 (1986).
V. M.-Y. Lee et al., ibid, 85, 1998 (1988).
V. M.-Y. Lee, L. Otvos, Jr., M. L. Schmidt, J. Q. Trojanowski, ibid, p. 7384.
L. Otvos et al., Int. J. Pept. Protein Res. 34, 129 (1989).
Y. Ihara, Brain Res. 459, 138 (1988).
N. W. Kowall and K. S. Kosik, Ann. Neurol. 22, 639 (1987).
A. C. McKee et al., ibid. 26, 652 (1989).
D. W. Cleveland, Cell. 60,701 (1990), G. Lee et al., Neuron 2, 1615 (1989).
S. A. Lewis et al., Nature 342, 498 (1989).
K. Iqbal et al., Proc. Natl. Acad. Sci. U.S.A. 86, 5646, (1989).
T. Miyakawa et al., Virchows Arch. B 57, 267 (1989).
G. McKhann et al., Neurology 34, 939 (1984).
Z. S. Khachaturian, Arch. Neurol. 42, 1097 (1985).
G. Lee et al., Neuron 2, 1615 (1989).

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