Method of detecting abnormal epitope expression on an immunocapt

Details Method of detecting abnormal epitope expression on an immunocapt Method of detecting abnormal epitope expression on an immunocapt

1994-07-07

1996-05-14

Spiegel, Carol A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 71, 435 794, 436518, 436528, 436531, 436824, G01N 3353

Patent

active

055166466

ABSTRACT:
A method is disclosed for detecting abnormal epitope expression of protein molecules by immunocapturing a constant number of protein molecules from a test and a reference sample using a limited amount of capturing antibodies, saturating them with its corresponding protein from the test and reference samples to provide a constant, known amount of the immobilized protein for comparison, labelling an epitope on the immobilized protein by means of a labelled probing antibody specifically reactive with the epitope and correlating any difference in labelling between the test and the reference sample to the absence or modification of the epitope in the protein of the test sample.

REFERENCES:
patent: 4703017 (1987-10-01), Campbell et al.
patent: 5187068 (1993-02-01), Luca
Linscott's Directory of Immunological and Biological Reagents, Fifth ed. 1988-1989, pp. 1-29, 31, 33-35,37-45, 53, 65,67,69,70 and 75.
American Diagnostics, Inc. Apr. 1991 Product List-Innovative Product for Research on and the Diagnosis of Clotting and Bleeding Disordes, pp. 10,12.
C. Birmingham (editor), Chemicon Communications, New Monoclonal Antibodies to Dystrophin (Spring 1992 pp. 2-3.

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