Method of detecting abnormal behavior of mammalian cells

Details Method of detecting abnormal behavior of mammalian cells Method of detecting abnormal behavior of mammalian cells

1974-09-12

1976-07-27

Borchelt, Archie R.

Radiant energy

Luminophor irradiation

With ultraviolet source

250302, G01N 2138

Patent

active

039719529

ABSTRACT:
Abnormal behavior of mammalian cells is detected in vitro by measuring the fluidity or an associated phenomenon of the lipid layer of the cell surface membrane. Abnormal behavior of cells, in particular if caused by malignant transformations, is associated with increase of fluidity of the liquid layer of the cell membrane, as compared with normal cells. The fluidity can be determined, e.g., by measuring the degree of fluorescence polarization of the radiation emitted from a suspension of cells labelled in the lipid layer with a fluorescent compound. 1,6-Diphenyl-1,3,5-hexatriene was found to be a suitable fluorescent probe.

REFERENCES:
patent: 3854050 (1974-12-01), Peterson et al.
patent: 3857033 (1974-12-01), Cobb
patent: 3864571 (1975-02-01), Stillman et al.

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