Method of designing agonists and antagonists to IGF receptor

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis

Reexamination Certificate

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C702S019000, C702S020000, C435S007200

Reexamination Certificate

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07020563

ABSTRACT:
Identification of the human insulin receptor binding site sequence of certain spatial molecular structures conforming to such binding site and of certain insulinomimetic sequences including the binding site sequence are disclosed.

REFERENCES:
patent: 5705335 (1998-01-01), Hendry
patent: WO 90/00562 (1990-01-01), None
“Crystallization of the first three domains of the human insulin-like growth factor-1 receptor”, N. McKern et al., Protein Science (1997), No. 6, pp. 2663-2666.
“Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor”, T. Garrett et al., Nature, vol. 394, Jul. 23, 1998, pp. 395-399.
Baserga, Renato, et al. “The IGF-I receptor in cell growth, transformation and apoptosis” Biochemica et Biophysica Acta, vol. 1332, Jun. 1997, pp. F105-F126.

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