Method of designing agonists and antagonists to EGF receptor...

Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis

Reexamination Certificate

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C702S019000, C702S020000, C435S007200

Reexamination Certificate

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06941229

ABSTRACT:
The present invention relates to a method of designing compounds able to bind to a molecule of the EGF receptor family and to modulate the activity mediated by the receptor molecule based on the 3-D structure coordinates of the EGF receptor crystal ofFIG. 6.

REFERENCES:
patent: 5705335 (1998-01-01), Hendry
patent: 5708156 (1998-01-01), Ilekis
patent: 94/25860 (1994-11-01), None
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McInnes, Cambell., et al. “NMR study of the transforming growth factor-alpha (TGF-alpha)-epidermal growth factor receptor complex. Visualization of human TGF-alpha binding determinants through nuclear Overhauser enhancement analysis.” Journal of Biological Chemistry, vol. 271, No. 50, 1996, pp. 32204-32211, XP002297752.
Sanchez, Roberto., et al. “Evaluation of Comparative Protein Structure Modeling by MODDELLER-3” Proteins, Structure, Function and Genetics, Suppl. Pp. 1:50-58 (1997.

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