Method of deprotection of 3-amino azetidinones

Details Method of deprotection of 3-amino azetidinones Method of deprotection of 3-amino azetidinones

1989-09-21

1991-01-08

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540205, 540222, 540224, 540226, 540229, 540230, 540363, 540364, 560 11, 560 17, C07B51100, C07D205095, C07D205085, C07D47104

Patent

active

049837320

ABSTRACT:
A method for preparing 2-amino-.beta.-lactams which are substituted by readily-removed protecting groups is provided. According to this invention, an acyl-2-amino-.beta.-lactam is further acylated with a different acyl group and is subsequently treated with base to provide a protected 2-amino .beta.-lactam with allyloxycarbonyl, t-butoxycarbonyl, naphthyloxycarbonyl, trichloroethyloxycarbonyl, p-nitrobenzyloxycarbonyl, benzhydryloxycarbonyl, p-methoxybenzyloxycarbonyl, or o-nitrobenzyloxycarbonyl.

REFERENCES:
patent: 3842077 (1974-10-01), Henniger
patent: 4052387 (1977-10-01), Kukolja
Micetich et al., Synth. Comm., 116(4) 453-460 (1986).
Grehn, J. Chem. Soc. Chem. Comm., 1985, p. 1317.

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