Drug – bio-affecting and body treating compositions – Dentifrices – Ferment containing
Patent
1981-07-01
1982-10-19
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
Ferment containing
424 54, 424 94, 132 89, 132 93, A61K 728, A61K 3748
Patent
active
043550223
ABSTRACT:
A dental and gum treatment agent and method uses the isolated and purified enzyme species lysozyme as a primary active substance to attack and destroy in situ the cariogenic bacteria in the oral cavity forming the plaque-calculus substrate and causing gum disorders. The agent operates to penetrate the bacterial cell wall and thereby destroy existing bacteria by disintegration so that residues are washed away. Auxiliary isolated enzymes of the groups of lipases, carbohydrases, phospholipases and proteases are used as additives to decrease treatment time as an aid to penetration of cell walls of gram (-) type bacteria. EDTA (ethylene diamino tetraacetic acid) is also used as an additive to remove ionic bonds that could clamp and stabilize bacterial walls to some extent after the lysozyme action. Thus, an aqueous solution of about 0.1 mg/ml of isolated lysozyme with or without controlled addition of known additives is effective in an oral cavity application for a few minutes to treat dental caries by removal of plaque and calculus, and to control gum infections.
REFERENCES:
patent: Re30675 (1981-07-01), Schole
patent: 656479 (1900-08-01), Schellenbach
patent: 1839486 (1932-01-01), Lawton
patent: 2748781 (1956-06-01), Collat
patent: 2975102 (1961-03-01), Matsumura et al.
patent: 3004897 (1961-10-01), Shore
patent: 3754332 (1973-08-01), Warren
patent: 3771536 (1973-11-01), Dragan
patent: 3830246 (1974-08-01), Gillings
patent: 3855142 (1974-12-01), Pader et al.
patent: 3929579 (1975-12-01), Hoshimura et al.
patent: 3940317 (1976-02-01), Katz et al.
patent: 3985869 (1976-10-01), Yoshimura et al.
patent: 4082841 (1978-04-01), Pader
patent: 4104125 (1978-08-01), Takechi et al.
patent: 4140758 (1979-02-01), Vidra et al.
patent: 4178362 (1979-12-01), Hoogendoorn et al.
patent: 4231381 (1980-11-01), Battista
patent: 4237911 (1980-12-01), White
patent: 4283385 (1981-08-01), Dhabhar et al.
C.A. 93: 120254c, 112370x (1980) 91: 129026w (1979) 89: 123774a: 80122s (1978).
C.A. 89: 204016g (1978) 88: 41681h: 65993n: 58352z (1978) 87: 145649z (1977).
C.A. 87: 189474t: 189443g: 11641g (1977) 86: 12216p: 127293d (1977).
C.A. 83: 188245z (1975) 80: 124773a (1974) 79: 133838g (1973) 77: 156342p (1972).
C.A. 77: 838a (1972) 76: 49949z: 1651u (1972) 75: 52803g (1971) 74: 10681q (1971).
C.A. 74: 74874n: 130404y: 79691k (1971) 66: 27872k (1967) 59#387a (1963) 56#13030d (1962).
Brown Laurence R.
Interon, Inc.
Rose Shep K.
LandOfFree
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