Method of delaying ejaculation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Reexamination Certificate

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Reexamination Certificate

active

06974839

ABSTRACT:
The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation.

REFERENCES:
patent: 3652589 (1972-03-01), Flick et al.
patent: 3830934 (1974-08-01), Flick et al.
patent: 4507323 (1985-03-01), Stern
patent: 4940731 (1990-07-01), Bick
patent: 5151448 (1992-09-01), Crenshaw et al.
patent: 5223541 (1993-06-01), Maryanoff et al.
patent: 5276042 (1994-01-01), Crenshaw et al.
patent: 5336691 (1994-08-01), Raffa et al.
patent: 5468744 (1995-11-01), Raffa et al.
patent: 5516803 (1996-05-01), Raffa
patent: 5591452 (1997-01-01), Miller et al.
patent: 5601842 (1997-02-01), Bartholomaeus
patent: 5723668 (1998-03-01), Buschmann et al.
patent: 5728885 (1998-03-01), Buschmann et al.
patent: 5801201 (1998-09-01), Graudums et al.
patent: 5811582 (1998-09-01), Buschmann et al.
patent: 5874620 (1999-02-01), Lerman et al.
patent: 5919826 (1999-07-01), Caruso
patent: 5922341 (1999-07-01), Smith et al.
patent: 5929122 (1999-07-01), Reimann
patent: 6017963 (2000-01-01), Alfonso et al.
patent: 6037360 (2000-03-01), Smith et al.
patent: 6090856 (2000-07-01), Sasaki
patent: 6156342 (2000-12-01), Sriwongjanya et al.
patent: 6228864 (2001-05-01), Smith et al.
patent: 6297286 (2001-10-01), Huckle
patent: 6339105 (2002-01-01), Kamin et al.
patent: 6369051 (2002-04-01), Jenkins
patent: 6376554 (2002-04-01), Cheetham et al.
patent: 6399618 (2002-06-01), Zolotoy et al.
patent: 6403597 (2002-06-01), Wilson et al.
patent: 2001/0049391 (2001-12-01), Alfonso et al.
patent: 2002/0052341 (2002-05-01), Fang et al.
patent: 2002/0055544 (2002-05-01), Kamin et al.
patent: 2 340 037 (2000-02-01), None
patent: WO 95/13072 (1994-11-01), None
patent: WO 99/21508 (1999-05-01), None
patent: WO 00/67729 (2000-11-01), None
patent: WO 01/17521 (2001-03-01), None
patent: WO 01/59084 (2001-08-01), None
patent: WO 02/41883 (2002-05-01), None
Wilder-Smith et al., Br. J. Clin. Pharmacol., 1997;43:71-75.
Jeffrey et al., British Journal of Anaesthesia, 1999; 83: 245-249.
Gobbi et al., European Journal of Pharmacology, 1999; 370:23-26.
Agmo et al., “Opioids and sexual behavior in the male rabbit: the role of central and peripheral opioid receptors”. J Neural Transm Gen Sect 1994; 97(e):211-23. (abstract) [Retrieved Apr. 15, 2003]. Retrieved from PubMed, PMID: 7873130.
Balfour et al., “Activation of Ventral Tegmental Neurons Following Sexual Behavior in Male Rats”, Horm. Behav., 39(4): 324 (2001).
Dunbar et al., “Concurrent Spinal Infusion of MK801 Blocks Spinal Tolerance and Dependence Induced by Chronic Intrathecal Morphine in the Rat”, Anesthesiology, V. 84, No. 5, 1996, pp 1177-1188.
Frink et al., “Influence of Tramadol on Neurotransmitter Systems of the Rat Brain”, Arzneim.-Forsch/Drug Res. 46 (II), Nr. 11 (1996), pp 1029-1036.
Gomez-Marrero et al., “Stimulation of opioid receptors suppresses penile erectile reflexes and seminal emission in rats”. In: Pharmacol Biochem Behav, Oct. 1988:31(2): 393-6 (abstract) [Retrieved Apr. 15, 2003]. Retrieved from PubMed, PMID 2854263.
Jaw et al., “Involvement of kappa-opioid receptors in opioid dependence/withdrawal: studies using butorphanol”. Eur J. Pharmacol, May 12, 1994, 247 (1-2): 153-60 (abstract) [Retrieved Apr. 15, 2003]. Retrieved from PubMed, PMID: 8082697.
Jaw et al., “Involvement of delta-opioid receptors in physical dependence on butorphanol”. Eur J Pharmacol, Aug. 10, 1993, 240 (1): 67-72 (abstract) [Retrieved Apr. 15, 2003]. Retrieved from PubMed, PMID: 8405123.
Jaw et al., “Opioid antagonists and butorphanol dependence”. Pharmacol Biochem Behav, Mar. 1993: 44(3) 497-500 (abstract) [Retrieved Jun. 16, 2002] Retrieved from PubMed, PMID: 8383850.
Leyton et al., “The stimulation of central kappa opioid receptors decreases male sexual behavior and locomotor activity”. Brain Res Oct. 23, 1992, 594(1): 56-74. (abstract) [Retrieved Apr. 15, 2003] Retrieved from PubMed, PMID: 1334765.
Matuszewich, “Bilateral injections of a selective mu-receptor agonist (morphiceptin) into the medial preoptic nucleus produces a marked delay in the initiation of sexual behavior in the male rat”. Psychopharmacology (Berl), 1992; 106(3): 391-6. (abstract) [Retrieved Apr. 15, 2003] Retrieved from PubMed, PMID: 1315063.
Melis et al. “Morphine injected into the paraventricular nucleus of the hypothalamus prevents noncontact penile erections and impairs copulation: involvement of nitric oxide.” Eur J Neurosci, Jun. 1999, 11(6): 1857-64. (abstract) [Retrieved Apr. 15, 2003] Retrieved from PubMed, PMID: 10336653.
Paredes et al., “What do female rats like about sex? Paced mating.” Behav Brain Res, Nov. 1, 1999; 105(1): 117-27. (abstract) [Retrieved May 1, 2003] Retrieved from PubMed, PMID: 10553695.
Rodriguez-Manzo et al., “Opioid antagonists and the sexual satiation phenomenon”. Psychopharmacology (Berl), Nov. 1995, 122(2): 131-6. (abstract) [Retrieved May 1, 2003] Retrieved from PubMed, PMID: 8848528.
Sanchez et al., “Comparison of the Effects of Antidepressants and Their Metabolites on Reuptake of Biogenic Amines and on Receptor Binding”, Cellular and Molecular Neurobiology, vol. 19, No. 4, 1999, pp 467-489.
Stahl, “Not So Selective Serotonin Reuptake Inhibitors”, Jul. 1998, [Retrieved Apr. 2, 2003 from http://www.psychiatrist.com/pcc/brainstorm/br5907.htm].
Trynke et al., “Citalopram alone does not, but combined with a silent 5-HT1Areceptor antagonist does inhibit male sexual behavior” [Retrieved Apr. 7, 2003 from http://www-nin.sci.kun.nl/NIN%20abstracts.htm].
Waldinger et al., “SSRIs and ejaculation: a double-blind, randomized, fixed-dose study with paroxetine and citalopram”. J Clin Psychopharmacol, Dec. 2001, 21(6): 556-60. (absract) [Retrieved Mar. 31, 2003] Retrieved from PubMed, PMID: 11763001.
Waldinger et al., “Antidepressants and ejaculation: a double-blind, randomized, placebo-controlled, fixed-dose study with paroxetine, sertraline, and nefazodone”. J Clin Psychopharmacol, Jun. 2001, 21(3): 293-7. (abstract) [Retrieved Mar. 31, 2003] Retrieved from PubMed, PMID: 11386492.
Waldinger et al., “Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline”. J Clin Psychopharmacol, Aug. 1998, 18(4): 274-81. (abstract) [Retrieved Mar. 31, 2003] Retrieved from PubMed, PMID: 9690692.
Olivier et al., “Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour”. Int Clin Psychopharmacol, Jul. 1998, 13 Suppl 6:S9-14, (abstract) [Retrieved Mar. 31, 2003] Retrieved from PubMed, PMID: 9728669.
Waldinger, “Selective serotonin reuptake inhibitor-induced sexual dysfunction clinical and research considerations”. Int Clin Psychopharmacol, Jul. 1998, 13 Suppl 6:S27-33. (abstract) [Retrieved Mar. 31, 2003] Retrieved from PubMed, PMID: 9728672.
Waldinger et al., “The selective serotonic re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment”. Psychopharmacology (Berl), Mar. 2002, 160(3):283-9. (abstract) [Retrieved Apr. 7, 2003] Retrieved from PubMed, PMID: 11889497.
Balfour et al., “MU Opioid Receptor Activation in Ventral Tegmental Neurons Following Sexual Behavior”, International Narcotics Research Conference, Monterey, CA, 2002.
Zarrindast et al., “Morphine inhibits dopaminergic and cholinergic induced ejaculation in rats”. In: Gen Pharmacol, Jul. 1994, 25(4):803-8. (abstract) [Retrieved May 1, 2003] Retrieved from PubMed, PMID: 7958745.
“Link Found Between Pain, Immune, and Reproductive Systems”, Indiana University School of Medicine, Apr. 21, 1997. [Retrieved Apr. 15, 2003 from http://medicine/indiana.edu/

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