Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1999-10-18
2000-12-05
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
A61K 31573
Patent
active
061567434
ABSTRACT:
A method of decreasing fatigue in humans who are shifting their time of wakefulness by administering an effective amount of hydrocortisone. The treatment is useful for those persons who must make an adjustment between their work hours and their usual sleep time such as night shift workers and those experiencing problems with jet lag.
REFERENCES:
McKenzie et al., JAMA, 280/20, 1061-66, Sep. 1998.
J.F. Waeckerle, "Circadian Rhythm, Shift Work and Emergency Physicians," Ann. Emerg. Med., (24) p. 959-961, (1994).
D.J. Skene, et al., "Use of Melatonin in Circadian Rhythm Disorders and Following Phase Shifts," Acta Neurobiol. Exp., (56) p. 359-36, (1996).
M. James, et al., "Can Melatonin Improve Adaptation to Night Shift?," Am. J. Emerg. Med., (6) p. 367-370, (1998).
S.W. Wright, et al., "Randomized Clinical Trial of Melatonin After Night-Shift Work: Efficacy an Neuropsycologic Effects," Ann. Emerg. Med., (3:3), p. 334-340, (1998).
M.M. Mitler, et al., "Catastrophes, Sleep, and Public Policy: Consensus Report," Sleep, (11:1), p. 100-109, (1988).
E.F. Mellor, "Shift work and flexitime: how prevalent are they?," Mon. Labor Rev., p. 14-21, (Nov. 1986).
F.G. Benedict, "Studies in Body-Temperature.--I. Influence of the Inversion of the Daily Routine; the Temperature of Night-Workers," Am. J. Physiolo., (1904), p. 145-169 (Admitted Prior Art).
P. Knauth, et al., "Experimental Shift Work Studies of Permanent Night, and Rapidly Rotating, Shift Systems," Int. Arch. Occup. Environ. Health, (46) p. 111-15, (1980).
S. Folklard, et al., "Short and Long-term Adjustment of Circadian Rhythms in `Permanent:` Night Nurses," Ergonomics, vol. 21 (10) p. 785-799, (1978).
William Harris, "Fatigue, Circadian Rhythm, and Truck Accidents," Vigilance: Theory, Operational Performance, and Physiological Correlates, Plenum (New York), p. 133-146, (1977).
J. Foret, G. Lantin, "The Sleep of Train Drivers: An Example of the Effects of Irregular Work Schedules on Sleep," Aspect of Human Efficiency Serial Rhythm, p. 273-282, (1970).
C.A. Czeisler, et al., "Exposure to Bright Light and Darkness to Treat Physiologic Maladaptation to Night Work," N. Engl. J. Med., (32:18) p. 1253-1259, (1990).
M.C. Moore-Ede, et al., "Cortisol-mediated synchronization of circadian rhythm in urinary potassium excretion," Am. J. Physiol., p. 230-38, (1977).
M.C. Moore-Ede and G.S. Richardson, "Medical Implications of Shift-Work," Am Rev. Med., (36) p. 607-617, (1985).
J. Aschoff, "Circadian Rhythms Within and Outside Their Ranges of Entrainment," Environmental Endocrinology, Springer-Verlag (New York), p. 172-181, (1978).
K.L. Keller and W.J. Koenig, "Management of Stress and Prevention of Burnout in Emergency Physicians," Ann. Emerg. Med., (18:1) p. 42-47, (1989).
S.L. Adams, et al., "Ambulatory Blood Pressure and Holter Monitoring of Emergency Physicians before, during and after a Night Shift," Acad. Emerg. Med., (5:9) p. 871-877, (1998).
R. Smith-Coggins, et al., "Rotating Shiftwork Schedules: Can We Enhance Physician Adaptation to Night Shifts?," Acad. Emerg. Med., (4:9) p. 951-961, (1977).
H.E. Michaels, "Night Shift Work," Ann. Emerg. Med., (13:3), p. 201-202, (Mar. 1984).
E.J. Bartle, et al., "The effects of acute sleep deprivation during residency training," Surgery, (104) p. 311-316, (1988).
H. Raff and J.W. Findling, "A New Immunoradiometric Assay for Corticotropin Evaluated in Normal Subjects and Patients with Cushing's Syndrome," Clin. Chem., (35:4) p. 596-600, (1989).
A. Munck, et al., "Physiological Functions of Glucocorticoids in Stress and Their Relation to Pharmacological Actions," Endocrine Reviews, (5:1) p. 25-44, (1984).
E.R. De Kloet, "Brain Corticosteriod Receptor Balance and Homeostatic Control," Frontiers in Neuroendocrinology, Raven Press, Ltd. (New York), (1:2) p. 95-164, (1991).
Hamilton Neil E.
Spivack Phyllis G.
LandOfFree
Method of decreasing fatigue does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of decreasing fatigue, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of decreasing fatigue will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-961876