Method of decellularizing tissues

Details Method of decellularizing tissues Method of decellularizing tissues

2004-05-12

2011-10-25

Ford, Allison (Department: 1653)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of detaching cells, digesting tissue or establishing...

C435S001100, C435S001200, C623S901000, C607S101000

Reexamination Certificate

active

08043854

ABSTRACT:
In the transplant of a living organism tissue, such as a heart valve, taken from an animal, etc. into a human body, a cell removing solution for removing original cells from the living organism tissue is provided with flow approximately equal to the bloodstream of transplant recipient living body, and the living organism tissue is placed in the flow so as to effect immersion of the living organism tissue in the cell removing solution. In the immersion, it is preferred that the living organism tissue placed in the cell removing solution, while being rotated, be irradiated with microwave. As a result, original cells can be removed from the living organism tissue uniformly and reliably, so that the biocompatibility of living organism tissue after transplant can be enhanced.

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Kiyotaka Iwasaki et al.; “Development of two types of novel bioreactors for decellularization and in vitro pulsatile conditioning of endothelial cells cultured on the porcine aortic valves”, The Japan Society of Mechanical Engineers, Mar. 13, 2003, pp. 83-84.
C. E. Visser et al.; “Microwave treatment of xenogeneic cartilage transplants”, Biomaterials, vol. 10, 1989, pp. 507-510.

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