Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Enzymatic production of a protein or polypeptide
Patent
1981-01-28
1983-09-13
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Enzymatic production of a protein or polypeptide
435243, 435244, 435172, C12P 2100, C12N 100, C12N 138, C12N 1500
Patent
active
044042795
ABSTRACT:
The invention relates to a method for increasing the hybridization of cells in vitro and for increasing the production and secretion of substances, formed by such cell hybrids by adding endothelial cells and/or the supernatant of endothelial cells to a hybrid culture. In particular the invention is concerned with a method for increasing the production of monoclonal antibodies in vitro by means of a hybridoma technique by adding endothelial cells and/or the supernatant of endothelial cells to a hybridoma culture. Usually human endothelial cells and/or the supernatant of human endothelial cells are used. Finally the invention relates to endothelial cells and/or the supernatant of endothelial cells for use for increasing the hybridization of cells in vitro and for increasing the production and secretion of substances, formed by such cell hybrids, and for increasing the production of monoclonal antibodies in vitro.
REFERENCES:
Astaldi et al.; Biol. Abstr. 71, 17274 (1981), Abstr. of Astaldi et al.; J. Immunol. 125, 1411-1414 (1980).
Nature, vol. 256, Aug. 7, 1975, pp. 494-497 G. Kohler et al.
Chemical Abstracts, vol. 89, No. 11, Sep. 11, 1978, p. 292, No. 87749K Columbus, Ohio, E. A. Jaffe et al. and J. Exp. Med. 1978, 147(6), 1779-1791.
Chemical Abstracts, vol. 91, No. 7, Aug. 13, 1979, p. 433, No. 53616R, Columbus Ohio, F. Grinnell et al. and Cell (Cambridge, Mass.) 1979, 17(1) 177-129.
Ricotti Giulia C. B. A.
Zeijlemaker Willem P.
Martinell James
Stichting Vrienden Van De Stichting Dr. Karl Landsteiner
Tanenholtz Alvin E.
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