Method of crystallizing .alpha.-L-aspartyl-L-phenylalanine methy

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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C07C10102

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active

053918100

ABSTRACT:
In crystallizing .alpha.-APM from a water solution or a mixed solvent solution of water and a lower alcohol in a crystallizer, the pressure in the crystallizer is held at not higher than atmospheric pressure, a water or water/alcohol mixed solution of .alpha.-APM is fed into the crystallizer with stirring so that the solvent is vaporized, and the crystallization solution is cooled and crystallized by the latent heat of vaporization or is heated so as to prevent supercooling.

REFERENCES:
patent: 4452621 (1982-09-01), Fowles
patent: 4994605 (1991-02-01), Kishimoto et al.

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