Method of crystallization of bicalutamide

Details Method of crystallization of bicalutamide Method of crystallization of bicalutamide

2005-07-13

2009-12-15

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C558S413000

Reexamination Certificate

active

07632971

ABSTRACT:
The present invention provides a method of crystallization of bicalutamide comprising adding an acetone solution containing bicalutamide to water; crystals of bicalutamide wherein particle size distribution of the crystals is 1 to 10 μm of Dp10, 10 to 25 μm of Dp50and 25 to 100 μm of Dp90, and the crystals are obtainable by the method described above; and crystals of bicalutamide, wherein particle size distribution of the crystals is 1 to 3 μm of Dp10, 2 to 5 μm of Dp50and 5 to 15 μm of Dp90.

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