Method of covalently bonding biopolymer to a solid hydrophilic o

Details Method of covalently bonding biopolymer to a solid hydrophilic o Method of covalently bonding biopolymer to a solid hydrophilic o

1991-09-13

1993-06-15

Nutter, Nathan M.

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

525 542, 525 5421, 525 5423, 525 543, 525 5431, 530403, 530404, 530405, 530413, 530417, 530811, 530812, 530813, 530814, 530815, 530816, 435 71, 435 74, 435 76, 435177, 435178, 435179, 435180, 435181, 436528, 436529, 436530, 436531, 436532, 436533, 436821, 436823, C07K 1708, C07K 300, C07K 1300, C12N 1108, C12N 1102, C12N 1106, C12N 1104, C12Q 100

Patent

active

052199266

ABSTRACT:
A process for covalently bonding biopolymer, such as protein, to an organic polymer surface coated with hydrophilic nonionic polymer having groups reactive with the biopolymer and having a cloud point in the reaction medium that is at least 5.degree. C. above the temperature at which the coated organic polymer surface is to be used, which comprises reacting biopolymer with the surface in an aqueous reaction medium, at a temperature not less than 5.degree. C. below the cloud point; but not above a temperature at which the biopolymer is deleteriously affected, and preferably not above about 100.degree. C., the product comprises a biopolymer immobilized on a hydrophilic solid surface having a nonionic polymer and a hydrophilic layer, coupled thereto via biopolymer-reactive groups of the nonionic polymer, and accordingly has low spontaneous adsorption of proteins and other biopolymers through electrostatic attraction and/or hydrophobic interaction.

REFERENCES:
patent: 4188263 (1980-02-01), Hulsmann et al.
patent: 4450231 (1984-05-01), Ozkan
Muzzarelli "Natural Chelating Polymers", Pergamon Press, Oxford, 1973, pp. ix-xii.
Webster's Ninth New Collegiate Dictionary, 1986, p. 152.

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