Method of correcting HERG channel dysfunction

Details Method of correcting HERG channel dysfunction Method of correcting HERG channel dysfunction

2006-03-14

2006-03-14

Hui, San-ming (Department: 1617)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

07012082

ABSTRACT:
A method of shortening prolonged QT intervals in a patient with a trafficking defective HERG mutation is disclosed. In one embodiment, this method comprises the step of treating the patient with an effective amount of fexofenadine whereby the patient's prolonged QT interval is shortened.

REFERENCES:
patent: 5869479 (1999-02-01), Kreutner et al.
patent: 5990147 (1999-11-01), Aslanian
patent: WO 01/46188 (2001-06-01), None
Q. Gong, et al., “Role of Glycosylation in Cell Surface Expression and Stability of HERG Potassium Channels,” Am. J. Physiol. Heart Cir. Physiol. 283:H77-H84, 2002.
C.T. Janaury, et al., “Long QT Syndrome: Cellular Basis and Arrhythmia Mechanism in LQT2,” J. Cardio. Electro. 11(12):1413-1418, 2000.
S. Rajamani, et al., “Pharmacological Rescue of Human K+ Channel Long-GT2 Mutations,” Circulation, pp. 2830-2835, 2002.
Z. Zhou, et al., “HERG Channel Dysfunction in Human Long QT Syndrome,” J. Biol. Chem. 273(33):21061-21066, 1998.
Z. Zhou, et al., “Correction of Defective Protein Trafficking of Mutant HERG Potassium Channel in Human Long AT Syndrome,” J. Biol. Chem. 274(44):31123-31126, 1999.

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