Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant...
Patent
1993-10-06
1996-12-03
Jordan, Charles T.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
250435, 422 63, 422100, 422159, A61K 5100
Patent
active
055805418
DESCRIPTION:
BRIEF SUMMARY
The invention relates to a method of conveying liquid materials in closed systems without mutual contamination.
Especially in hospitals and clinics often hazardous liquid materials are handled. Preferably such materials are kept in closed systems as much as possible to diminish the risk of contamination of the environment, including the attendant personnel, with such materials. It is always difficult to avoid contamination of such liquid materials with other liquid materials, e.g. rinsing fluids, or, vice versa, of these rinsing fluids with such hazardous liquid materials in closed systems. In the former case undesired dilution of the hazardous liquid material, e.g. a pharmaceutical liquid, takes place, in the latter case the rinsing fluid is no longer environmentally unsuspected. Conventionally the system is flushed with an inert gas, e.g. nitrogen, to remove the first liquid material as far as possible before introducing the second liquid material.
More in particular the present invention relates to a method as mentioned in the opening paragraph, comprising the steps of (i) introducing a first liquid material into a main conduit through a first inflow conduit provided with a first valve, (ii) closing said first valve and flushing said main conduit with an inert gas, (iti) stopping the flushing operation and introducing a second material into said main conduit through a second inflow conduit provided with a second valve, (iv) closing said second valve and repeating said flushing operation, and (v), optionally after introducing in a corresponding manner a third liquid material through a third inflow conduit with valve, repeating the above operations. It has been observed, however, that after the flushing operation an aliquot of the liquid material, just introduced into the main conduit, is still present between the valve and the connection between inflow conduit and main conduit, said aliquot with its convex outer surface projecting into the main conduit. Part of this aliquot is entrained by the other liquid material, next introduced into the main conduit, and consequently contaminates this latter liquid material.
According to the present invention it has now been found, that this problem can be avoided by using a peristaltic pump for the introduction of the liquid materials into the main conduit and by making said pump to rotate for a moment in the reverse direction after each flushing operation. By taking the above measures, mutual contamination of the liquid materials can be avoided completely. Peristaltic pumps are to be understood to comprise tube pumps.
It will be clear from the above, that the method of the invention is intended in particular for conveying liquid materials, one of which is a pharmaceutical liquid, especially a radiopharmaceutical liquid. A radiopharmaceutical liquid is notoriously hazardous for the environment. In general the other liquid will be a rinsing liquid, intended for removing the radioactivity from the closed system, i.e. the main conduit, as completely as possible.
The above method according to the present invention is pre-eminently suitable for use in an automated system for elution and delivery of radiopharmaceutical liquids. Consequently, the present invention also relates to a method for the automated elution of a radionuclide generator and delivery of a radiopharmaceutical liquid, in particular a Tc99m-pertechnetate solution, in a generator-eluting and delivery device, comprising a mutually connected solvent reservoir, radionuclide generator, pump means, eluate reservoir and delivery station, said method comprising the steps of (a) rinsing of the interconnecting means by flushing said means with a solvent, (b) program-controlled elution of said generator with a predetermined quantity of said solvent and transfer of the resulting eluate to said eluate reservoir, the radioactivity of the eluate in the reservoir being continuously monitored, (c) program-controlled discharge of a predetermined quantity of the eluate and, if desired, simultaneously a predetermined quantit
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Kettle Andrew G.
Wells Charles P.
Hardet John R.
Jordan Charles T.
Mallinkrodt Medical, Inc.
McBride Thomas P.
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