Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1995-03-14
1997-03-25
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514 34, 514632, A01N 3744, A61K 31195
Patent
active
056145578
ABSTRACT:
.alpha.-Fluoromethyl- or .alpha.-difluoromethylornithine, and certain derivatives thereof, can be used alone or in combination with cytotoxic agents for the treatment of neoplastic diseases.
REFERENCES:
patent: 2662915 (1953-12-01), Lontz et al.
patent: 3168558 (1965-02-01), Kurhajec et al.
patent: 4207315 (1980-06-01), Voorhees et al.
patent: 4288601 (1981-09-01), Kollonitsch
patent: 4325961 (1982-04-01), Kollonitsch
patent: 4418077 (1983-11-01), Bey
patent: 4423073 (1983-12-01), Gerhart
patent: 4439619 (1984-03-01), Bey
patent: 4446151 (1984-05-01), Gerhart
H-A. Williams et al., De Italian J. Biochem. 25, pp. 5-32 (1976).
Raiwa et al., Medical Biology 53, pp. 121-147 (1975).
Russell, Life Sciences, 13, pp. 1635-1647 (1973).
Janfe et al., Biochem and Biophys. Res Comm. 42, pp. 222-229 (1971).
Pegg et al, Biochem, J. 108, pp. 533-539 (1968).
Organic Synthesis, III, pp. 440-442 (1955).
Synthesis pp. 791-793 (1973).
Hackh's "Chemical Dictionary" 4th Ed. Copyright renewed 1972. McGraw-Hill bl. p. 36.
Pauling, Linus "The Nature of the Chemical Bond" 2nd Ed. Cornell University Press. (1948) p. 60.
Relyea, Noel et al. "Potent inhibition of ornithine decarboxylase by beta-gamma-unsaturated substrate analogs." Biochem. Biophysics Res. Commun. 1975 67(1) 392-402.
Rando, Robert R. "Chemistry and Enzymology of k.sub.cat Inhibitors." Science, vol. 185 pp. 320-324. (Jul. 26, 1974).
Viterro et al, Tetrahedron letters pp. 4617-4620 (1971).
Dunzendorfer et al., Cancer Research 38, pp. 2321-2324 (1978).
Rando, "Chemistry, Enzymology of K.sub.C3 T Inhibitors" Science, vol. 185, pp. 320-324 (Jul. 26, 1974).
J. of Medicinal Chemistry, vol. 17, No. 4, pp. 447-451 (1974) and vol. 18, No. 6, pp. 600-604 (1975).
Burger, Medicinal Chemistry, 3rd Ed., Part I, Pub. Wiley Interscience, N.Y., pp. 65, 70-72 (1970).
Clinical Aspects of Inhibition of Ornithine Decarboxylase With Emphasis on Therapeutic Trials of Eflornithine (DFMO) in Cancer and Protozoan Diseases - Chapter 16 of Inhibition of Polyamine Metabolism, P. McCann, A. Pegg and A. Sjoerdsma (1987).
Bey Philippe
Jung Michel
Goldberg Jerome D.
Marion Merrell et Compagnie C/O Merrell Pharmaceuticals Inc.
Wille Louis J.
LandOfFree
Method of controlling tumor growth rate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of controlling tumor growth rate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of controlling tumor growth rate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2203925