Method of controlling the serum solubility of orally administere

Details Method of controlling the serum solubility of orally administere Method of controlling the serum solubility of orally administere

1998-06-02

1999-06-22

Jordan, Kimberly

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514869, A61K 3144

Patent

active

059143363

ABSTRACT:
A method of controlling the serum solubility of orally administered torasemide is disclosed. A new crystallin modification of torasemide, called modification III which has significantly higher rates of solubilization than the known crystallin form of torasemide, modification I, is blended with amounts of modification I to produce a preselected level of torasemide in serum at a given time following administration. Compositions containing amounts of modification I and modification III, sufficient to achieve the desired serum levels of torasemide, are also disclosed.

REFERENCES:
patent: Re34580 (1994-04-01), Topfmeier et al.
patent: Re34672 (1994-07-01), Topfmeier et al.

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