Method of controlling the regioselectivity of glycosidic bonds

Details Method of controlling the regioselectivity of glycosidic bonds Method of controlling the regioselectivity of glycosidic bonds

1986-12-04

1990-04-17

Wax, Robert

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

435 96, 435 18, 435 22, 435 74, 435 85, 435 98, 435200, 435201, 435207, 435208, 536 41, 536 174, 536 176, C12P 1964, C12N 924

Patent

active

049180096

ABSTRACT:
A method of controlling the regioselectivity of the glycosidic bond between glycosyl donor and glycosyl acceptor in the enzymatic production of an oligosaccharide compound which either consists of or is a fragment or an analog of the cabohydrate part in a glycoconjugate, by reverse hydrolysis or transglycosidation reactions, is described. The synthesis is carried out in that a donor substance which is a mono- or oligosaccharide or a glycoside thereof, is caused to react, in the presence of a glycosidase, with an acceptor substance which is an O-, N-, C- or S-glycoside consisting of a monosaccharide, oligosaccharide or a saccharide analog and at least one aglycon which is O-, N-, C- or S-glycosidically bonded in 1-position, the .alpha. or .beta.-configuration being selected on the glycoside bond between the glycosyl group and the aglycon in the acceptor substance, and the oligosaccharide compound being separated from the reaction mixture.

REFERENCES:
patent: 4225672 (1980-09-01), Hall
patent: 4544631 (1985-10-01), Rauscher et al.
patent: 4675392 (1987-06-01), Dahmen et al.
patent: 4762917 (1988-08-01), Ikenaka et al.
Enzyme Nomenclature, Academic Press, New York (1979) pp. 274-294.
Chang, T. M. S., "Microencapsulation of Enzymes and Biologicals", in Methods in Enzymology vol XLIV, (1976) pp. 201-203, 211-213.

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