Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1975-11-14
1977-08-23
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 19, 424 36, 424228, 424229, 424359, A61K 926, A61K 3118, A61K 964
Patent
active
040441199
ABSTRACT:
An oral dosage medicinal composition for ruminant animals is provided which is processed in a manner to cause a medically effective amount of drug contained therein to be slowly released to the animal by virtue of distribution of the medicament throughout a dry, essentially water-insoluble, slowly digestible matrix. Even slower but therapeutically effective drug release is unexpectedly experienced in feverish animals. A compressed dosage form for oral administration is prepared by first treating an admixture of originally essentially undenatured native milk solids and the drug with a sufficient quantity of an aldehydic agent to insolubilize the milk protein solids. This treated composition is then preferably granulated and the granules compressed under sufficient pressure to form a densified body which is not only resistant to disintegration for over 24 hours when tumbled in water, but also has a specific gravity at least greater than about 1 to cause the dosage form upon administration to a ruminant animal to have a tendency to sink in the rumino-recticular fluids and become entrapped in the rumino-recticular compartments.
REFERENCES:
patent: 629141 (1899-07-01), Weyland
patent: 1021674 (1912-03-01), Horowitz
patent: 2406741 (1946-09-01), Compton et al.
patent: 2519487 (1950-08-01), Macek
patent: 2656298 (1953-10-01), Loewe
patent: 2889248 (1959-06-01), Paterson
patent: 3275519 (1966-09-01), Glassman
patent: 3590117 (1971-06-01), Christenson et al.
Barber et al. Agriculture 63:111-114 (1956) "Formalin-Treated Skim Milk for Pigs".
Mitchell et al. J. Dairy Res. 27: 103-114 (1960) "Restricted and and Lib. Feeding of Liquid Skim-Milk, with and without the addition of formalin, to fattoning pigs."
Carlson, Jr. Arthur
Rupe Billy D.
Cutter Laboratories, Inc.
Rose Shep K.
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