Method of controlling release of an active or drug from a silico

Details Method of controlling release of an active or drug from a silico Method of controlling release of an active or drug from a silico

1995-08-02

1997-01-28

Marquis, Melvyn I.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

528 15, A61K 914

Patent

active

055975844

ABSTRACT:
The instant invention pertains to a method of controlling release of active agents or drugs from a silicone rubber matrix by controlling the degree of crosslinking in the silicone rubber matrix. The silicone rubber matrixes of the instant invention are produced from liquid silicone rubbers comprised of (A) a polyorganosiloxane containing at least two alkenyl radicals per molecule; (B) an organohydrogensiloxane containing at least two silicon-bonded hydrogen atoms per molecule; and (C) a hydrosilylation catalyst in an amount sufficient to promote curing of said composition.

REFERENCES:
patent: 4814184 (1989-03-01), Aquadisch et al.
Pfister, Fraleigh and Walters, "Characterization of a New Polydimethylsiloxane Elastomer Resistant to Drug Induced Cure Inhibition; Matrix for Controlled Drug Delivery"; Presented at the 17th International Symposium on Controlled Release of Bioactive Materials, Jul. 22-25 1990, Reno Nevada. Proceed. Intern. Symp. Control Rel. Bioact. Mater. 17:277-278 (1990).

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