Method of controlling nephrotoxicity of anti-tumor plaintum comp

Details Method of controlling nephrotoxicity of anti-tumor plaintum comp Method of controlling nephrotoxicity of anti-tumor plaintum comp

1989-04-24

1991-03-26

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424649, 514492, A61K 4900, A61K 3324, A61K 3128

Patent

active

050027557

ABSTRACT:
Nephrotoxicity of anti-tumor platinum coordination compounds (e.g., cisplatin) is reduced by administering a dithiocarbamate chelator (e.g., diethyldithiocarbamate) at least 12 hours before as well as immediately after the administration of the anti-tumor compound.

REFERENCES:
patent: 4426372 (1984-01-01), Borch
Juckett et al., Am. Assoc. Cawc. Res. Proc. (1984) 25:322 (Abst 1274) and (1985) 373 (Abst 1472).
Shiwobu et al., Acta Pharmacol. et Toxicol (1984) 54:189-194.

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