Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1995-12-11
1997-09-30
Spivack, Phyllis G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
A61K 3158
Patent
active
056725957
ABSTRACT:
A method of controlling male fertility in warm-blooded male animals comprising administering to male warm-blooded animals an amount of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are taken together with the nitrogen to form a saturated 5 to 6 ring heterocycle, optionally containing a second nitrogen or oxygen in the ring, R.sub.3 is .alpha.- or .beta.-methyl, n is an integer from 2 to 10, R.sub.4 and R.sub.5 together are .dbd.0 or R.sub.4 is selected from the group consisting of hydrogen, --OH and acyloxy of an organic carboxylic acid of up to 12 carbon atoms and R.sub.5 is selected from the group consisting of hydrogen, --OH, acyloxy of an organic carboxylic acid of up to 12 carbon atoms and alkyl, alkenyl and alkynyl of up to 8 carbon atoms, R.sub.6 and R.sub.7 together are .dbd.0 or are individually selected from the group consisting of hydrogen, --OH and acyloxy of an organic carboxylic acid of up to 12 carbon atoms or R.sub.5 and R.sub.6 form a double bond and R.sub.4 and R.sub.7 are hydrogen and their non-toxic, pharmaceutically, acceptable acid addition salts in an amount sufficient to control male fertility.
REFERENCES:
Journal of Pharmacy and Pharmacology, The Pharmaceutical Society of Great Britain, vol. 16, No. II D.D. Evans, et al., pp. 717-724.
Estrogenic Activities of Some 3-Alkoxyestra-1,3,5(10)-trien-17Beta-ols, C. Liarakos, et al., pp. 1247-1249, vol. 84, Center for Theoretical Bio. May 1969.
Bonfils Armelle
Philibert Daniel
Roussel Uclaf
Spivack Phyllis G.
LandOfFree
Method of controlling male fertility does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of controlling male fertility, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of controlling male fertility will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2256744