Method of controlling male fertility

Details Method of controlling male fertility Method of controlling male fertility

1996-03-14

1996-12-03

Spivack, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 31565

Patent

active

055808646

ABSTRACT:
A method of controlling male fertility in warm-blooded male animals comprising administering to male warm-blooded animals an amount of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of alkyl of 1 to 8 carbon atoms and benzyl, R.sub.3 is a .alpha.- or .beta.-methyl, n is an integer from 2 to 10, R.sub.4 is hydrogen, R.sub.5 is hydrogen, R.sub.6 and R.sub.7 are hydrogen, and their non-toxic, pharmaceutically acceptable acid addition salts in an amount sufficient to control male fertility.

REFERENCES:
Chemical Abstracts CA 60:3039h (1964).
Journal of Pharmacy and Pharmacology, The Pharmaceutical Society of Great Britain, vol. 16, No. II, D. D. Evans, et al., pp. 717-724, 1964.
Chem. Abstracts, vol. 58, 13012, B. Barnard, 1963.
Estrogenic Activities of Some 3-Alkoxyestra-1, 3, 5(10)-trien-17Beta-ols, C. Liarakos, et al., pp. 1247-1249, vol. 84, Center for Theoretical Bio., 1969.

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