Method of controlling hypertension using monoclonal antibodies t

Details Method of controlling hypertension using monoclonal antibodies t Method of controlling hypertension using monoclonal antibodies t

1987-01-02

1990-03-27

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Lymphokine

530387, 530316, 530806, 530808, 530809, 530807, 514 2, 514 8, 514 16, 43524027, 4351722, 435 3, 435 7, 435104, 436548, 436512, A61K 39395

Patent

active

049119095

ABSTRACT:
Monoclonal antibodies to angiotensin II and the continuous hybrid monoclonal cell lines for their production are provided. These antibodies are useful in the diagnosis and treatment of angiotensin II-induced hypertension.

REFERENCES:
patent: 4376110 (1983-03-01), David et al.
patent: 4804626 (1986-10-01), Wands et al.
Picard et al., Immunol., 57 (1), 19-24, (Jan. 1986).
Carretero et al., Fed Proc., 30(2), 432, Abs. 1319, 1971.
Markle et al., PNAS, 75(11), 5702-5 (1978).
Fed. Proc., Abs #'s 2643, 2646, 2647, 1986, in 37(3), (1978).
Navar et al., Fed Proc., 45(5), 1448-53, (1986 (Apr.)).
Caldwell et al., FEBS Lett., 63(1), 82-4, (1976).
Kreofsky et al., Fed. Proc., 45(6), p. 1576, Abs 556, 1986.
Sevier et al., (in Chem., 27(11), 17-97-1806, (1981).
Pierre-Olivier Couraud, "Structure Analysis of the Epitopes Recognized by Monoclonal Antibodies to Angiotensin II", 136 J. Immunology 3365-3370 (No. 9, 5/1/86).
Jurg Nussberger, et al., "A Monoclonal Antibody Specific for the Carboxy-Terminus of Angiotensin II", 3 Hybridoma 373-376 (No. 4, 1984).
Taisuke Inagaki, et al., "Mouse Submaxillary Renin has a Protease Activity and Converts Human Plasma Inactive Prorenin to an Active Form", 258 J. Biological Chemistry 7476-7480 (No. 12, 1983).
J. H. Silas, et al., "Captopril Induced Reversible Renal Failure: A Marker of Renal Artery Stenosis Affecting a Solitary Kidney", 286 Brit. Med. J. 1702-3, (5/28/83).
M. Worcel, et al., "The Role of Angiotensin: Indirect Studies with Antiangiotensin Plasma", Supp II to XXVI, XXVII Circulation Research 11-223-11-234, (Oct. 1970).
J. Bing, et al., "Effect of Anti-angiotensin II on Blood Pressure and Sensitivity to Angiotensin and Renin", A.78 Acta path. microbiol. scand. 6-18 (1970).
H. R. Brunner, et al., "The Present Molecules of Converting Enzyme Inhibitors", 7 J. Cardiovascular Pharmacology S2-S11 (1985).
P. R. Hedwall, "Effect of Rabbit Antibodies Against Angiotensin-II on the Pressor Response to Angiotensin-II and Renal Hypertension in the Rat", 34 Br. J. Pharmac. 623-629 (1968).
V. J. Dzau (Haber), et al., "Comparison of Renin-specific IgG and Antibody Fragments in Studies of Blood Pressure Regulation", 0363-6135/84 Am. Physiological Soc. H404-H409 (1984).
J. Nussberger, et al., "Selectivity of Angiotens in II Antisera", 56 J. Immunological Methods 85-96 (1983).
G. Kohler, et al., "Continuous Cultures of Fused Cells Secreting Antibody of Predefined Specificity", 256 Nature 495-497 (No. 5517, 8/7/75).
H. R. Brunner, "Angiotensin II Vascular Receptors: Their Avidity in Relationship to Sodium Balance, the Autonomic Nervous System, and Hypertension", 51 J. Clinical Investigation 58-67 (1972).
Dzau, 7 J. Cardiovascular Pharmacol. S53 (1985).
Packer, et al., 315 N. Eng. J. Med. 847 (1986).
Walker, et al., Proc. Fifth Int'l. Cong. of Nephrology 1115 (1972).

Affiliated with

Also associated with

Rating

Method of controlling hypertension using monoclonal antibodies t does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of controlling hypertension using monoclonal antibodies t, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of controlling hypertension using monoclonal antibodies t will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1649626