Method of controlling fertilization using bombesin or its agonis

Details Method of controlling fertilization using bombesin or its agonis Method of controlling fertilization using bombesin or its agonis

1992-07-27

1995-08-08

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 514 15, A61K 3810, A61K 3817

Patent

active

054398843

ABSTRACT:
A method of promoting or blocking fertilization, which method includes the step of contacting sperm either at the time of sperm capacitation or at the time of egg fertilization with an effective amount of bombesin or its analog capable of stimulating or inhibiting the acrosome reaction.

REFERENCES:
patent: 5112596 (1992-05-01), Malfroy-Cahne
L. Gnessi et al., "Identificaiton of immunoreactive gastrin-releasing peptide related substances in adult rat leydig cells" Endocrinology 124:558, 1989.
L. Gnessi et al., "Isolation of a human seminal plasma peptide with bombesin-like activity" Fertil. Steril. 51:1034, 1989.
L. Gnessi et al., "Gastrin-releasing peptide-like immunoreactivity in porcine follicular fluid and ovary" Mol. Cell Endocrinol. 66:115, 1989.

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