Method of controlling density of ligand coupled onto supports an

Catalyst – solid sorbent – or support therefor: product or process – Solid sorbent – Organic

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502401, 502403, 502159, 502162, 502168, 502172, B01J 2026

Patent

active

055610978

ABSTRACT:
A method is disclosed for controlling the coupling low molecular weight ligands to activated sites on a support in competition with a quencher of the activated sites. Derivatized supports produced by the method have optimal ligate binding without overly dense binding sites or stearic effects. Azlactone-functional supports, especially porous supports such as porous particles, benefit from control of ligand density. A linear relationship exists between the molar ratio of ligand and quencher and the coupled ligand density. Optionally, hydrophilicity of the derivatized support can be determined by selection of quencher relative to selection of ligand.

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