Chemistry: molecular biology and microbiology – Condition responsive control process
Patent
1986-03-25
1990-01-02
Rosen, Sam
Chemistry: molecular biology and microbiology
Condition responsive control process
4352401, 4352402, 435243, 435244, 4352523, 43525233, 43525231, C12Q 300
Patent
active
048913103
ABSTRACT:
A method of controlling culture wherein cells are aerobically cultured to produce metabolite is characterized by adding substrate and/or inducer to the culture broth, judging the endpoint of the growth of the cells and/or the production of the metabolite or terminating the culture under the guidance of a change in the ratio of the first parameter based on the amount of carbon dioxide evolved by the cell culture to the second parameter based on the amount of oxygen consumed by the cell culture. The ratio is a respiratory quotient, for instance.
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Fukuzono Shinichi
Nishimura Nobuko
Odawara Yoji
Shimizu Norio
Sumitani Tomoaki
Hitachi , Ltd.
Rosen Sam
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