Method of controlling and determining germicidal activity

Chemistry: analytical and immunological testing – Halogen containing – In aqueous solution

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424 80, 436178, G01N 3300

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active

045754918

ABSTRACT:
Iodine-containing germicidal preparations are provided with assured control of the content of equilibrium iodine in aqueous solution to be between 1 and 20 ppm, preferably 2-15 ppm so as to provide predetermined germicidal activity. The invention further comprises the determination of the content of equilibrium iodine in an aqueous iodophor solution by subjecting such solution to several extractions with different amounts of a water immiscible solvent for iodine, determining the concentrations of the equilibrium iodine in each of the amounts of the water immiscible solvent and extrapolating the concentrations to a theoretical zero value which is a measure of the equilibrium iodine in the aqueous iodophor solution. The invention further comprises improved germicidal iodophor compositions comprising an iodophor, citric acid and iodate.

REFERENCES:
patent: 3028300 (1962-04-01), Cantor et al.
patent: 4320114 (1982-03-01), Denzinger et al.
Prutton et al., "Fundamental Principles of Physical Chemistry", The Macmillan Co., New York, 1951, pp. 376-383.
Daniels et al., "Physical Chemistry-Third Edition", John Wiley & Sons, New York, 1966, pp. 173-176.

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