Method of control of gastrointestinal bleeding

Details Method of control of gastrointestinal bleeding Method of control of gastrointestinal bleeding

1978-01-06

1983-03-22

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

424330, A61K 3700, A61K 31135

Patent

active

043775730

ABSTRACT:
Norepinephrine has been found as useful in a method of treatment to control gastrointestinal bleeding when injected directly into the portal blood supply by direct injection into either the peritoneal cavity or the gastrointestine i.e. intragastrically. A dose unit for such administration is also described.
The method of administration described prevents systemic vasoconstriction and consequent serious hypertension in the patient. Passage through the liver inactivates the compound.

REFERENCES:
patent: 3371080 (1968-02-01), Boissonnas
patent: 3671636 (1972-06-01), Saari
Remington's Pharmaceutical Sciences, Martin et al, Mack Pub. Co., Easton, Pa. (1965) pp. 957-958.
The American Journal of Surgery, Feb. Issue pp. 144-159, 1972.
Annals of Surgery, vol. 175, #4, Apr. 1972, pp. 459-465.

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