Method of continuous production of retroviruses (HTLV-III) from

Details Method of continuous production of retroviruses (HTLV-III) from Method of continuous production of retroviruses (HTLV-III) from

1984-08-24

1987-03-24

Warren, Charles F.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Recovery or purification

435240, 435948, 435 5, 435 29, 436527, C12N 702, C12N 500, C12Q 170, C12Q 102

Patent

active

046525998

ABSTRACT:
A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with the acquired immune deficiency syndrome (AIDS), pre-AIDS and in healthy carriers. One neoplastic aneuploid T-cell line derived from an adult with lymphoid leukemia, and termed HT, was susceptible to infection with HTLV-III, which is transformed and provides T-cell populations which are highly susceptible to and permissive for HTLV-III, and convenient for large scale production, isolation, and biological detection of the virus. Other operational neoplastic T-cell lines which are positive for OKT4 marker, e.g., Molt 3, CEM, Ti7.4 and HUT78, can produce HTLV-III in a large amount and retain its unlimited capability for growth.

REFERENCES:
patent: 4520113 (1985-05-01), Gallo et al.
Essex et al, "Antibodies to Cell Membrane Antigens Associated with Human T-Cell Leukemia Virus in Patients with AIDS", Science, 220, pp. 859-862 (5-1983).
Gallo et al, "Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)", Science, 220, pp. 865-867 (5-1983).
Barre-Sinoussi et al, "Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency", Science, 220, pp. 868-871 (5-1983).
Popovic et al, Science, 224:497, May 4, 1984.
Sarngadharan et al, Science, 224:506, May 4, 1984.
Schupbach et al, Science, 224:503, May 4, 1984.

Affiliated with

Also associated with

Rating

Method of continuous production of retroviruses (HTLV-III) from does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of continuous production of retroviruses (HTLV-III) from , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of continuous production of retroviruses (HTLV-III) from will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1354314