Method of continuous production of retroviruses (HTLV-III) from

Details Method of continuous production of retroviruses (HTLV-III) from Method of continuous production of retroviruses (HTLV-III) from

1984-04-23

1987-03-03

Warren, Charles F.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

Recovery or purification

435235, 435240, 435948, 424 89, C12N 702, C12N 700, C12N 500, C12R 191

Patent

active

046477730

ABSTRACT:
A cell system is disclosed for the reproducible detection and isolation of human T-lymphotropic retroviruses (HTLV-family) with cytopathic effects (HTLV-III) from patients with the acquired immune deficiency syndrome (AIDS), pre-AIDS and in healthy carriers. One neoplastic aneuploid T-cell line derived from an adult with lymphoid leukemia, and termed HT, was susceptible to infection with the new variants of HTLV, which are transformed and providing T-cell populations which are highly susceptible and permissive from HTLV-III, and convenience for large scale production, isolation and biological detection of the virus.

REFERENCES:
patent: 4464465 (1984-08-01), Lostrom et al.
patent: 4520113 (1985-05-01), Gallo et al.
Popovic et al, Science, 224(4648):497-500, May 4, 1984.
Gallo et al, "Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)", Science, 220, pp. 865-867 (5-1983).
Barre-Sinoussi et al, "Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for AIDS", Science, 220, pp. 868-871 (5-1983).
Marx, "Strong New Candidate for AIDS Agent", Science, 224, pp. 475-477 (5-1984).

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