Method of conjugating oligopeptides

Details Method of conjugating oligopeptides Method of conjugating oligopeptides

1982-07-09

1984-12-11

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

525 5411, C07C10352, C08L 8900

Patent

active

044877153

ABSTRACT:
Novel methods are provided for preparing peptide compounds involving functionalizing an available amino group with a carboxy group, esterifying the carboxy group with an hydroxylic compound which forms an ester which is stable under the conditions of cleavage of the oligopeptide from said resin, but which ester is capable of forming a peptide bond with an amino group in an aqueous medium, and without separation, either allowing the oligopeptide to react with itself or with a polypeptide compound.

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