Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical
Patent
1994-03-23
1996-12-03
Fleisher, Mindy
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing saccharide radical
435 911, 435 913, 4351723, 4352401, 4352402, 4353201, 536 231, C12N 1511, C12N 510, C07H 2102, C07H 2104
Patent
active
055807615
ABSTRACT:
In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective viral particles. The method involves introducing a vector into a host cell, wherein the vector comprises a polynucleotide which directs transcription, within the host cell, of RNA which is a) complementary or corresponding, depending on the target region, to a nucleic acid sequence within one or more regions of the genome of the retrovirus; and b) is effective in inhibiting one or more steps in the retroviral infection process by interfering with retroviral replication, reverse transcription, translation, or assembly into viral particles when the host cell is infected. Also disclosed is a method of treatment using the nucleic acid constructs, or cells upon which resistance to infection has been conferred.
REFERENCES:
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R. Tellier et al. (1985) Nature 318:414.
H. Mitsuya et al. (1987) Nature 325:773-778.
L.-J. Chang et al. (1987) Journal of Virology 61(3):921-924.
M. I. Johnston et al. (1993) Science 260:1286-1293.
S. M. Sullivan et al. (1992) Antisense Research and Development 2:187-197.
Greatbatch Wilson
Sanford John C.
Fleisher Mindy
Greatbatch Gen-Aid Ltd.
Railey II Johnny F.
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