Method of conferring immuno-tolerance to a specific antigen

Details Method of conferring immuno-tolerance to a specific antigen Method of conferring immuno-tolerance to a specific antigen

1987-03-20

1990-02-27

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

424 8591, 424 86, 424 87, 424 88, 424 89, 424 90, 424 91, 424 92, 435 7, 435810, 436548, 436547, 436512, 436506, 436808, 514885, 530387, 530391, 530389, 530388, A61K 3900, A61K 39395

Patent

active

049044818

ABSTRACT:
A method of selectively suppressing the immune system and conferring immunotolerance against a specific antigen by interferring with the L3T4 differentiation antigens on helper T cells is described. Simultaneous administration of a binding moiety specific for the L3T4-equivalent in the subject species and a specific antigen or administration of the antigen subsequent to the binding moiety for L3T4-equivalent within the time required for T-cell recovery results in a diminished ability of the subject to respond immunologically to the antigen, whether or not the subject has been exposed previously to the antigen.

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