Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1999-03-05
2000-12-26
Le, Long V.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
210515, 210782, 435 71, 435 721, 435 6, 435 23, 435 24, 436518, 436528, 436536, 436538, 436539, 436547, 436825, 436524, 436174, 436175, 436176, 436177, 530402, 530403, 530412, 530413, 530418, 530419, 530420, 530421, 530355, 4241471, 4241301, A23J 100, G01N 100, G01N 3353, G01N 33567, B01D 1200, A61K 3942
Patent
active
061661872
ABSTRACT:
A sample is prepared from blood in a manner which makes it possible to further analyze proteins in the sample, e.g. to detect prions in the sample. Blood is extracted, allowed to clot and subjected to separation processing (e.g. centrifugation) to obtain serum. The serum is treated with a complexing agent which agent binds prions in the sample forming an agent/protein complex which makes it possible to concentrate the complex. Concentration of the complex results in a sample which can be successfully analyzed, e.g. assayed using a range of different types of assay methodologies for detecting prions.
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Prusiner Stanley B.
Safar Jiri G.
Bozicevic Karl
Gabel Gailene R.
Le Long V.
The Regents of the University of California
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