Method of combating mammalian neoplasias, and lytic peptides the

Details Method of combating mammalian neoplasias, and lytic peptides the Method of combating mammalian neoplasias, and lytic peptides the

1995-06-01

1998-06-30

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 530324, 530326, 530327, A61K 3816, C07K 708, C07K 1400

Patent

active

057734135

ABSTRACT:
A method of treating neoplasias, including female mammalian neoplasias such as breast, cervical, uterine, and ovarian neoplasias, as well as other neoplasias including prostatic, dermal, and bronchogenic cancers, comprising delivery of an effective non-naturally occurring, non-cytologically proliferative lytic peptide to an appropriate corporeal site to effectively treat such disease state. Particlularly preferred lytic peptide agents include small (23-39 amino acids) amphipathic cationic lytic peptides from the classes of synthetic analog derivatives of mellittin, cecropin, magainin, and defensin peptides, most preferably melittic and defensin peptides from the class of synthetic analogs of melittin, cecropin, maganin, and defensin peptides, most preferably synthetic analogs of melittic and defensin peptides.

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