Chemistry: analytical and immunological testing – Clotting or clotting factor level tests
Patent
1988-08-17
1989-10-03
Hill, Jr., Robert J.
Chemistry: analytical and immunological testing
Clotting or clotting factor level tests
435 13, 436176, 436 18, G01N 3386
Patent
active
048716774
ABSTRACT:
An inhibitor of platelet-related procoagulant activity is included in a collection medium into which a whole blood sample is collected. The inhibitor prevents an initial drop in the recalcified activated clotting time measured during an assay test conducted on the whole blood sample collected in citrate in the medium. The discovery of the problem of the initial drop in the activated clotting time and the solution of including the inhibitor of the procoagulant activity is of considerable importance in heparin therapy, since the initial drop in the activated clotting time of heparinized blood is substantial. The inhibitor can be included with a calcium chelating agent in the collection medium. Prostacylin and imidazole, which is an inhibitor of platelet thromboxane A2 synthesis, are effective inhibitors of this platelet-related procoagulant activity.
REFERENCES:
patent: 4067777 (1978-01-01), Innerfield et al.
patent: 4116635 (1978-09-01), Jaeger
patent: 4243671 (1981-01-01), Harris et al.
patent: 4359463 (1982-11-01), Rock
patent: 4540801 (1985-09-01), Nysted et al.
Baugh Robert F.
Taylor Cynthia A.
HemoTec, Inc.
Hill Jr. Robert J.
Ley John R.
Polumbus Gary M.
Wallen T. J.
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