Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Nitrates or nitrites or nitric acid or nitrogen oxides
Reexamination Certificate
2003-12-10
2011-12-13
Saucier, Sandra (Department: 1657)
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Nitrates or nitrites or nitric acid or nitrogen oxides
C514S013400, C514S013500, C514S021920
Reexamination Certificate
active
08075922
ABSTRACT:
Contrary to current opinion that nitrite in general oxidizes hemoglobin with elimination of active nitric oxide, deoxygenated hemoglobin reacts with low concentration inorganic nitrite to produce very stable iron nitrosyl hemoglobin which on delivery into the body is converted to a hemoglobin capable of nitric oxide delivery and provides vasodilator and antiplatelet activity. This provides basis for ameliorated risk blood product transfusions.
REFERENCES:
patent: 4820269 (1989-04-01), Riddell
patent: 6124255 (2000-09-01), Schlag et al.
patent: 6291424 (2001-09-01), Stamler et al.
patent: WO 96/30006 (1996-10-01), None
patent: WO-97009972 (1997-03-01), None
patent: WO-98/34955 (1998-08-01), None
patent: WO-99/01146 (1999-01-01), None
patent: WO 01/09616 (2001-02-01), None
patent: WO-03102575 (2003-12-01), None
Nelle et al., “Effects of red cell transfusion on cardiac output and blood flow velocities in cerebral and gastrointestinal arteries in premature infants”, Archives of Disease in Childhood. Fetal and Neonatal Edition, 71 (1) : F45-8 (1994).
Carson et al., “Perioperative Blood Transfusion and Postoperative Mortality”, JAMA 279 (3) : 199-205 )1998).
Engoren et al., “Long-term survival in the Intensive Care Unit after Erythrocyte Blood Transfusion”, American J. Critical Care : an official pulication, America Assoc. of Critical-Care Nurses 18 (2) : 124-31 (2009), abstract only.
Remy et al., “Modified hemoglobins: Contributions and perspectives”, Schweizerische Medizinische Wochemschrift 127 (25):1088-1096 (1997), abstract only.
Johnson III et al., “Cardioprotective Effects of Acidified Sodium Nitrite in Myocardial Ischemia with Reperfusion”, Journal of Pharmacology and Experimental Therapeutics 252 (1) : 35-41 (1990).
Jaening et al., Uber die Reaktion zwischen Natriumnitrit and Hemoglobin IV. Umsetzung in Abwesenheit von Sauerstoff. Acta Biologica et Medica Germanica (1970), vol. 25, No. 2, pp. 355-358.
Alayash et al., “Hemoglobin-based blood substitutes: oxygen carriers, pressor agents, or oxidants?”, Nature Biotechnology, 17:545-549 (1999).
Reiter et al., “Cell-free hemoglobin limits nitric oxide bioavailability in sickle cell disease”, Nature Medicine, 8(12): 1383-1389 (2002).
Singel David J.
Stamler Jonathan S.
Duke University
Elrifi Ivor R.
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
Montana State University-Bozeman
Pavao Matthew
LandOfFree
Method of co-infusing a deoxygenated hemoglobin containing... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of co-infusing a deoxygenated hemoglobin containing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of co-infusing a deoxygenated hemoglobin containing... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4261252