Method of cleaving specific strands of RNA and medical treatment

Details Method of cleaving specific strands of RNA and medical treatment Method of cleaving specific strands of RNA and medical treatment

1995-06-01

1997-10-14

Rories, Charles C.P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Pyrethrum plant derived material or plant derived rotenone...

514 46, 514 47, 436 94, 435 6, 435 911, 435199, 4352402, 536 245, 536 252, A61K 3170, A61K 4800, C07H 2100, C12Q 168

Patent

active

056772890

ABSTRACT:
A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.

REFERENCES:
Dialog File 636: IAC Newsletter DB (TM), #02944476-"Conference Coverage (ICAAC) Antisense Drug Stumbles in Early Trial".
R. Weiss, Science News, vol. 139 (Feb. 16, 1991) pp. 108-109.
C. Stein et al., Science, vol. 261 (Aug. 20, 1993) pp. 1004-1012.
M. Johnston et al., Interferon, vol. 3 (1984) pp. 332-334 & ref pages.
P. Defilippi et al., FEBS Letters, vol. 198(2) (Mar. 1986) pp. 326-332.
J. Chebath et al., Nature, vol. 330 (Dec. 10, 1987) pp. 587-588.
E. Uhlmann et al., Chem. Rev., vol. 90 (4) (Jun. 1990) pp. 543-584.
P. Westermann et al., Biomed. Biochem. Acta, vol. 48(1) (1989) pp. 85-93.
B. Tseng et al., Cancer Gene Therapy, vol. 1 (1) (Mar. 1994) pp. 65-71.
D. Krause et al., JBC, vol. 260(16) (Aug. 5, 1984) pp. 9501-9507.
P. Torrence et al., JBC, vol. 263(3) pp. 1131-1139 (1989).
K. Kariko et al., Biochem, vol. 25 (1986) pp. 3730-3736.
D. Wreschner et al., Nature, vol. 289(1981) pp. 414-417.
Y. Li et al., PNAS, vol. 89 (Apr. 1992) pp. 3185-3189.
R. Walder et al, PNAS, vol. 85 (Jul. 1988) pp. 5011-5015.
J. Goodchild et al., vol. 1(3) BioOrganic Chem, (90) pp. 165-187.
P. Miller et al., Anticancer Drug Design (1987) vol. 2, pp. 117-128.

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