Method of cleaving specific strands of RNA

Details Method of cleaving specific strands of RNA Method of cleaving specific strands of RNA

1993-09-17

1996-12-10

Rories, Charles C. P.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 6, 435 911, 435199, 514 44, 514 46, 514 47, 536 245, 536 251, 536 252, 536 253, 436 94, C02H 506, C07H 2102, C08J 300, C12Q 168

Patent

active

055830323

ABSTRACT:
A method of using a chimeric molecule made up of an antisense oligonucleotide attached to a 2',5'-oligoadenylate molecule to specifically cleave a sense strand of RNA, wherein the antisense oligonucleotide of the chimeric molecule is hybridized to the sense strand of RNA in the presence of 2',5'-dependent RNase.

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