Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-08-02
2011-08-02
Prouty, Rebecca (Department: 1657)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07989175
ABSTRACT:
A method for classifying human subjects having adolescent idiopathic scoliosis (AIS) into AIS subgroups, comprising detecting an impairment in the melatonin-signaling pathway in a cell sample from the subject, wherein the impairment is detected by an accumulation of cyclic adenosine 5′-monophosphate (cAMP) in the cell sample as compared to a control sample in the presence of a known melatonin-signaling pathway agonist, wherein the results of the detection step enable the classification of the subject having AIS into an AIS subgroup.
REFERENCES:
patent: 0 892 046 (1999-01-01), None
patent: WO 95 35320 (1995-12-01), None
patent: WO 98 03549 (1998-01-01), None
patent: WO 01 09383 (2001-02-01), None
patent: WO 03 073102 (2003-09-01), None
Axenovich et al. “Segregation analysis of idiopathic scoliosis: demonstration of a major gene effect”, (1999), Am J Med Genet;, vol. 86(4):389-394.
Bagnall et al., “The effects of melatonin therapy on the development of scoliosis after pinealectomy in the chicken”, (1999), J Bone Joint Surg Am, vol. 81(2):191-199.
Bagnall et al. “Melatonin levels in idiopathic scoliosis. Diurnal and nocturnal serum melatonin levels in girls with adolescent . . . ”(1996), Spine; vol. 21(17): 1974-1978.
Bagnall et al., “Pineal transplantation after pinealectomy in young chicken has no effect on the development of scoliosis”, (2001) Spine, vol. 26, No. 9: 1022-1027.
Beuerlein et al., “Development of Scoliosis Following Pinealectomy in Young Chickens Is Not the Results of . . . ” (2001), Microscopy Research and Technique, vol. 53: 81-86.
Blank et al., “A genomic approach to scoliosis pathogenesis”, (1999), Lupus; vol. 8(5):356-360.
Borjigin et al., “The pineal gland and melatonin: molecular and pharmacologic regulation”, (1999), Annu Rev Pharmacol Toxicol; vol. 39:53-65.
Brodner et al., “Melatonin and adolescent idiopathic scoliosis”. (2000), J Bone Joint Surg Br; vol. 82(3):399-403.
Bruls et al., “Melatonin. I. Physiology of its secretion”, (2000) Rev. Med. Leige, vol. 55, No. 8: 785-792, (Abstract).
Cardinali et al., “Melatonin site and mechanism of action: single or multiple?”, (1997), J Pineal Res; vol. 23(1):32-39.
Cheng et al., Persistent osteopenia in adolescent idiopathic scoliosis. A longitudinal follow up study, (1999), Spine, vol. 24(12):1218-1222.
Cheng et al., “Osteopenia in adolescent idiopathic scoliosis: a histomorphometric study”, (2001), Spine; vol. 26(3):E19-E23.
Cheung et al., “Effect of Melatonin Suppression on Scoliosis Development in Chickens . . . ”, (2003), Spine vol. 28, No. 17 pp. 1941-1944.
Cheung et al., “The Effect of Pinealectomy on Scoliosis Development in Young Nonhuman Primates”, (2005), Spine vol. 30, No. 18 pp. 2009-2013.
Connor et al., “Genetic aspects of early childhood scoliosis”, (1987), Am J Med Genet; vol. 27(2):419-424.
Conway et al, “Chimeric melatonin mt1 and melatonin-related receptors: Identification of domains and residues . . . ”, Journal of Biol. Chem., vol. 275, No. 27: 20602-20609.
Courtois et al., “Bone mineral density at the femur and lumbar spine in a population of young women treated for scoliosis . . . ”, (1999), Rev Rhum Engl Ed, vol. 66(12):705-710.
Cowburn et al., “Preservation of Gi-protein inhibited adenylyl cyclase activity in the brains of patients with Alzheimer's disease”, (1992), Neurosci Lett; 141(1):16-20.
De Georges et al., “Idiopathic Scoliosis: Genetic and Enrironmental Aspects”, (1967), J. med. Genet., vol. 4: 251-257.
Drazen et al. , “Melatonin enhancement of splenocyte proliferation is attenuated . . . ”,(2001) Am. J. Physiol. Regulatory Integrative Comp Physiol., vol. 280 pp. R1476-R1482.
Fagan et al., Total 24-Hour Melatonin Secretion in Adolescent Idiopathic Scoliosis: A Case-Control Study, (1998), Spine vol. 23, No. 1 pp. 41-46.
Feldman RD. “Insulin-mediated sensitization of adenylyl cyclase activation”, (1993), Br J Pharmacol; vol. 110(4):1640-1644.
Garcia-Perganeda et al., “Signal Transduction for Melatonin in Human Lymphocytes”, The Journal of Immunology, vol. 159 (1997) pp. 3774-3781.
Giampietro et al. “Synteny-defined candidate genes for congenital and idiopathic scoliosis”, (1999), Am J Med Genet; 83(3):164-177.
Hans et al., “No diffuse osteoporosis in lumbar scoliosis but lower femoral bone density on the convexity”, (1996), Bone; vol. 18(1):15-17.
Hilibrand et al., “The Role of Melatonin in the Pathogenesis of Adolescent Idiopathic Scoliosis”, (1996), Spine vol. 21, No. 10, pp. 1140-1146.
Hyatt et al., “Initiation of vertebrate left-right axis formation by maternal Vg1”, (1996), Nature, vol. 384:62-65.
Iuvone et al., “Melatonin Receptor-Medicated Inhibition of Cyclic AMP Accumulation in Chick Retinal Cell Cultures”, (1994), Journal of Neurochemistry, vol. 63, No. 1: 118-124.
Jockers et al., “Structure and function of melatonin receptors”, (1998), C R Soc Biol., vol. 192(4):659-667.
Kaziro et al., “Structure and function of signal-transducing GTP-binding proteins”, (1991) Annu Rev Biochem, vol. 60:349-400.
Kennaway, D. J., “Melatonin and development: Physiology and Pharmacology”, (2000) Seminars in Perinatology, vol. 24, No. 4: 258-266.
Machida et al., “Pathogenesis of idiopathic scoliosis. Experimental study in rats”, (1999), Spine; vol. 24(19):1985-1989.
McCarrey et al., “Genetics of scoliosis in chickens”, (1981), J Hered, vol. 72 (1):6-10.
Nakade et al., “Melatonin stimulates proliferation and type I collagen synthesis in human bone cells in vitro” (1999), J Pineal Res; vol. 27(2):106-110.
O'Kelly et al., The Production of Scoliosis After Pinealectomy in Young Chickens, Rats, and Hamsters, (1999), Spine vol. 24, No. 1, pp. 35-43.
Papaioannou et al., “G-protein signaling pathways and oestrogen: a role of balanced maintenance in osteoblasts”. (1999) Biochim Biophys Acta; vol. 1449(3): 284-292.
Purkiss et al., “Idiopathic Scoliosis in Families of Children With Congenital Scoliosis”, (2002), Clin Orthop Relat Res No. 401, pp. 27-31.
Roka et al., “Tight association of the human Mel(1a)-melatonin receptor and G(i): precoupling and constitutive activity”, (1999), Mol Pharmacol, vol. 56(5):1014-1024.
Roth et al., “Melatonin promotes osteoblast differentiation and bone formation”, (1999), J Biol Chem; vol. 274(31):22041-22047.
Sadat-Ali et al., Adolescent idiopathic scoliosis. Is low melatonin a cause?, (2000) Joint Bone Spine; 67(1):62-64.
Sjoblom et al., “Peripheral melatonin mediates neural stimulation of duodenal mucosal . . . ”, (2001), The Journal of Clinical Investigation, vol. 108, No. 4: 625-633.
Tintut et al., “Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells . . . ”, (1999), J Biol Chem; vol. 274(41):28875-28879.
von Gall et al. “Transcription factor dynamics and neuroendocrine signaling in the mouse pineal gland . . . ”, (2000), Eur J Neurosci; vol. 12(3):964-972.
Wang et al., “Changes in serum melatonin levels in response to pinealectomy in the chicken and its correlation with . . . ”, (1998), Spine; vol. 23(22):2377-2381.
Wise et al., “Localization of susceptibility to familial idiopathic scoliosis”, (2000), Spine; vol. 25(18):2372-2380.
Whynne-Davies Ruth, “Familial (Idiopathic) Scoliosis”, (1968), The Journal of Bone and Joint Surgery, vol. 50B, No. 1: 24-30.
Gauvreau Julie
Goudreau Gage Dubuc
Hopital Sainte-Justine
Martin Paul
Prouty Rebecca
LandOfFree
Method of classifying human subjects having adolescent... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of classifying human subjects having adolescent..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of classifying human subjects having adolescent... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2780755