Method of chlorinating side chain of 2-chloro-methylpyridine

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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546346, C07D21326, C07D21361

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active

053248414

ABSTRACT:
The invention relates to a method of chlorinating a side chain methyl group of 2-chloro-methylpyridine. The method comprising the steps of:(a) reacting said 2-chloro-methylpyridine with chlorine radical so that hydrogen chloride and/or hydrochloride of 2-chloro-methylpyridine are formed; and (b) neutralizing said hydrogen chloride and/or said hydrochloride of said 2-chloro-methyl-pyridine with a basic solution so as to chlorinating a side chain methyl group of said 2-chloro-methylpyridine.

REFERENCES:
patent: 4612377 (1986-09-01), Osborne
patent: 4778896 (1988-10-01), Gallenkamp
patent: 5198549 (1993-03-01), Gunther
CA 116:83696u, Guenther et al, (DE:4016175), Nov. 1991.
Chem. Abstracts, vol. 84, 1976, Abs. No. 121665p, T. Hattori et al.
Angewandte Chemie, vol. 75, 1963, (Weinheim), pp. 235-240.

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