Method of characterisation

Details Method of characterisation Method of characterisation

1995-04-05

1998-09-22

Campbell, Eggerton A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, C12Q 168, C12P 1934

Patent

active

058112359

ABSTRACT:
A method of characterizing a test sample of genomic DNA which method comprises amplifying a tandemly repeated region, comprising more than one type of repeat unit, as far as internal repeat units of a specific type so as to generate a set of amplification products which identify the relative positions of the internal repeat units within the tandemly repeated region, and separating the set of amplification products to provide a sample code. The sample codes are suitable for computerized storage on, and retrieval from, a database. The invention also provides a novel method for the detection of diagnostic base sequences in one or more nucleic acids contained in a sample.

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patent: 5175082 (1992-12-01), Jeffreys
Jeffreys et al, "Minisatellite repeat coding as a digital approach to DNA typing", Nature 354:204-29 (1991).
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Monckton et al, "Minisatellite Isoallele Discrimination in Pseudohomozygotes by Single Molecule PCR and Variant Repeat Mapping", Genomics 11:465-467 (1991).
Gibbs, "DNA Amplification by the Polymerase Chain Reaction", Anal. Chem. 62:1202-1214 (1990).
U.S. Patent Application Ser. No. 07/504,591--Suldiner et al, "RNA Template-Specific Polymerase Chain Reaction".
Honghua et al., Nature 335:414-417 (1988) "Amplification and analysis of DNA sequences in . . . ".
Mullis et al., Cold Spring Harbor Symposia on Qunt. Biol:L1:263-273 (1986) "Specific enzymatic amplification of DNA . . . ".
Weber et al., Am. J. Hum. Genet. 44:388-396 (1989) "Abundant Class of Human DNA Polymorphisms . . . ".
Far et al., Nature 354:184 (1991) "New variations on the theme".

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