Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1986-06-23
1989-05-30
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530333, C07K 710
Patent
active
048352519
ABSTRACT:
Production of human relaxin or novel human relaxin analogs by combination of a human relaxin A-chain and B-chain comprises combining the reduced form of the human relaxin A-chain and the reduced form of the human relaxin B-chain in an aqueous medium having a pH of about 7.0 to 12 at room temperature, under conditions that are mildly denaturing for the relaxin B-chain such that the human relaxin or novel human relaxin analog can be formed.
REFERENCES:
patent: 4421685 (1983-12-01), Chance
patent: 4656249 (1987-04-01), Florey
patent: 4758516 (1988-07-01), Hudson et al.
Chance et al., Peptides, Synthesis-Structure-Function, Rich and Gross, eds., Rockford, Pierce Chemical Co. Press, pp. 721-728 (1981).
Johnston et al., Ninth American Peptide Symposium, Abstracts, Jun. 23-28, 1985, P-MTu-118, p. 109.
Johnston et al., Ninth American Peptide Symposium, Poster, Jun. 23-28, 1985.
Tregear et al., Biology of Relaxin and Its Role in the Human, Bigazzi et al., Eds., Proceedings of the 1st International Conference on Human Relaxin, Florence, Sep. 30-Oct. 2, 1982, pp. 42-55.
Blundell, T. et al., in Biology of Relaxin and Its Role in the Human, (Exc. Med., Amster.) pp. 14-21, Bigazzi, et al. (eds) 1983.
Busse, W. D. and Carpenter, F. H. Biochemistry, 15: 1649-1657 (1976).
Hudson P. et al., The EMBO Journal, 3: 2333-2339 (1984).
Hudson, P. et al., Nature, 301: 628-631 (1983).
James, R. et al., Nature, 267: 544 (1977).
Johnston, P. D. et al., in Peptides: Structure & Function, Proc. 9th American Peptide Sympos. (Pierce Chem. Co.), Deber et al. (ed) 1985.
Katsoyannis, P. G. et al., Biochemistry, 6: 2656-2668 (1967).
Schwabe, C. and McDonald, J. R., Science 197: 914-915 (1977).
Tregear, G. et al., in Relaxin; (Elsevier, N.Y.), Bryant-Greenwood et al. (eds), 1981, pp. 151-164 "The Synthesis of Peptides with Relaxin Activity".
Kung et al., Scientia Sinica, 15: 544 (1966).
Burnier John P.
Johnston Paul D.
Genetech, Inc.
Hasak Janet E.
Phillips Delbert R.
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