Method of catalyzing chemical reactions

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 91, 435105, 435108, 435 41, 435193, 435196, 435199, 435207, 935106, 935108, 530387, C12P 1900, C12P 1934, C12P 1902, C12P 1322, C12P 100, C12N 910, C12N 916, C12N 922, C12N 938, C12N 1500, C07K 1300

Patent

active

048882810

ABSTRACT:
A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the formation of a complex between the antibody and the reactant. The complexed reactant is converted to the product which is then released from the complex. The monoclonal antibody may employ a cofactor and may be directed to a known substrate of an enzyme. Methods for preparing such monoclonal antibodies are also disclosed.

REFERENCES:
patent: 4486530 (1984-12-01), Davis et al.
patent: 4492751 (1985-01-01), Boguslaski et al.
patent: 4493890 (1985-01-01), Morris
patent: 4659567 (1987-04-01), Tramontano et al.
patent: 4792446 (1988-12-01), Kim et al.
Enzyme Nomenclature, pp. 274, 278 and 279, 1979.
Sacks, D. et al., J. Experimental Med., vol. 155, pp. 1108-1119, 1982.
Frackelton et al., J. Biol. Chem., vol. 255, pp. 5286-5290, 1980.
Roberts, R. J., Meth in Enzymology, vol. 68, pp. 27-31, 1979.
White et al., Princ. of Biochemistry, pp. 200, 217-221, 573, 575-585, 1968.
David et al., Clin. Chem., vol. 27, pp. 1580-1585, 1981.
Melcners et al., Biochem. Biophys. Res. Comm., vol. 40(3), pp. 570-575, 1970.
Pollack, S. et al., Science, vol. 234, pp. 1570-1573, 1986.
Tramontano, A. et al., Science, vol. 234, pp. 1566-1570, 1986.
Research News, Science, vol. 234, pp. 1497-1498, 1986.
Lawrence I. Slobin, "Preparation and Some Properties of Antibodies with Specificity towards p-nitrophenyl Esters", Biochemistry 5:2836-2844, (1966).
V. Raso and B. D. Stollar, "The Antibody-Enzyme Analogy, Characterization of Antibodies to Phosphopyridoxyltyrosine Derivatives," Biochemistry, 15:584-591, (1975).
V. Raso and B. D. Stollar, "The Antibody-Enzyme Analogy, Characterization of Enzymes and Antibodies Specific for Phosphopyridoxyltyrosine," Biochemistry, 14:591-599, (1975).
J. K. Burd, R. J. Carrico et al., "Specific Protein-Binding Reactions Monitored by Enzymatic Hydrolysis of Ligands-Fluorescent Dye Conjugates", Analytical Biochemistry, 77:56-67, (1975).
F. Kohen et al., "A Steroid Immunoassay Based on Antibody-Enhanced Hydrolysis of a Steroid Umbelliferone Conjugate", FEBS Letters, 100:137-140, (1979).
F. Kohen et al., "Nonradioisotopic Homogeneous Steroid Immunoassays", J. Steroid Biochemistry, 11:161-167, (1979).
F. Kohen et al., "Antibody-Enhanced Hydrolysis of Steroid Esters", Biochemica et Biophysica Acta, 629:328-337, (1980).
F. Kohen et al., "Monoclonal Immunoglobulin G Augments Hydrolysis of an Ester of the Homologous Hapten," FEBS Letters, 111:427-431, (1980).
W. P. Jencks, "Catalysis In Chemistry And Enzymology", p. 288, (McGraw Hill, New York, 1969);
G. P. Royer, "Enzyme-Like Synthetic Catalysts, (Synzymes,"; Advances in Catalysis, 29, pp. 197-227, (1980);
J. B. Summers, Jr., "Catalytic Principles of Enzyme Chemistry: Antibody Models And Stereoelectronic Control", Harvard University Ph. D. Thesis, pp. 22-101, (1983), (UMI Dissertation Information Service, (1984).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of catalyzing chemical reactions does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of catalyzing chemical reactions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of catalyzing chemical reactions will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1902487

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.