Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2007-04-17
2007-04-17
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C514S025000, C514S033000, C514S034000
Reexamination Certificate
active
11150461
ABSTRACT:
This invention comprises a method of treating a subject having relapsed or refractory cancer such as leukemia with liposomal annamycin including the steps of(a) evaluating the subject to determine if the subject has relapsed or refractory cancer;(b) administering a high-dose amount of liposomal-annamycin for at least 3 days in a 7 day period. First line cancer therapy with particular reference to leukemia is both contemplated and useful.
REFERENCES:
patent: 5811119 (1998-09-01), Mehta et al.
patent: 5821254 (1998-10-01), Sporn et al.
patent: 5874412 (1999-02-01), Priebe et al.
patent: 5902604 (1999-05-01), Zou et al.
patent: 6929802 (2005-08-01), Andreeff et al.
Perez-Soler, Cancer Research, vol. 50, pp. 4260-4266, 1990.
Zou, Cancer Research, vol. 54, pp. 1479-1484, 1984.
Perez-Soler, Cnacer Chemother. Pharmacol. vol. 34, pp. 109-118, 1994.□□.
Consoli, Blood, vol. 88, pp. 633-644, 1996□□Devita, Principles of Chemotherapy, ED., Philadelphia, 1993.
Acton et al., “Intensely potent morpholinyl anthracyclines,”J. Med. Chem., 27:638-645, 1984.
Barbieri et al., “Chemical and biological characterization of 4′-iodo-4′ deoxydoxorubicin,”Cancer Res., 47:4001-4006, 1987.
Chaudhary and Roninson, “Induction of multidrug resistance in human cells by transient exposure to difference chemotherapeutic drugs,”J. Natl. Cancer Inst., 85:632-639, 1993.
Consoli et al., The novel anthracycline annamycin is not affected by p-glycoprotein-related multidrug resistance: comparison with idarubicin and doxorubicin in HL-60 leukemia cells lines,Blood, 88(2):633-644, 1996.
Dalton, “Overcoming the multidrug-resistant phenotype,”Principles and Practice of Oncology, 4thEd., 6:2655-2666, Philadelphia, 1993.
Den Boer et al., “Optimal immunocytochemical and flow cytometric detetection of P-gp, MRP and LRP in childhood acute lymphoblastic leukemia,”Leukemia, 11:1078-1085, 1997.
DeVita et al., “Principles of chemotherapy”,Principles and Practice of Oncology, 4thEd., Philadephia, 1993.
Gabizon et al., “Liposomes asin vivocarriers of adriamycin: reduced cardiac uptake and preserved antitumor activity in mice,”Cancer Res., 42:4734-4739, 1982.
Ganapathi et al., “N-benzyladriamycin-14-valerate versus progressively doxorubicin-resistant murine tumors: cellular pharmacology and characterization of cross-resistancein vitroandin vivo,”Br. J. Cancer, 60:819-826, 1989.
Hermann et al., “Prevention of chronic doxorubicin cardiotoxicity in beagles by liposomal encapsulation,”Cancer Res., 43:5427-5432, 1983.
Leith et al., “Correlation of multidrug resistance (MDRI) protein expression with functional dye/drug efflux in acute myeloid leukemia by multiparameter flow cytometry: identification of discordant MDR−/efflux+and MDRI+/efflux−cases,”Blood, 86:2329-2343, 1995.
Marie, “Phenotypic and genotypic analyses of multidrug resistance (MDR) in clinical hospital practice,”Leukemia, 11:1063-1066, 1997.
Mayhew et al., Inhibition of liver metastases of M 5076 tumor by liposome-entrapped adriamycin,Cancer Drug Delivery, 1:43-57, 1983.
Moscow and Cowan, “Multidrug resistance,”J. Natl. Cancer Inst., 80:14-20, 1989.
Perez-Soler and Priebe, “Anthracycline antibodies with high liposome entrapment; structural features and biological activity,”Cancer Res., 50:4260-4266, 1990.
Priebe et al., “Removal of the basic center from doxorubicin partially overcomes multidrug resistance and decreases cardiotoxicity,”Anticancer Drugs, 4:37-48, 1993.
Rahman et al., Comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes,Cancer Res., 46:2295-2299, 1986.
Zou et al., Antitumor activity of free and liposome-entrapped annamycin, a lipophilic anthracycline antibiotic with non-cross-resistance properties, ABSTRACT,Cancer Res., 54:1479-1484, 1994.
Zou et al., “Organ distribution and tumor uptake of annamycin, a new anthracycline derivative with high affinity for lipid membranes, entrapped in multilamellar vesicles,”Cancer Chemother. Pharmacol., 32:190-196, 1993.
Zou et al., “Quantitative analysis of the lipophilic doxorubicin analog annamycin in plasma and tissue samples by reverse-phase chromatography,”J. Pharm Sciences, 82:1151-1154, 1993.
Andreeff Michael
Estey Elihu H
Board of Regents , The University of Texas System
Fulbright & Jaworski L.L.P.
Kishore Gollamudi S.
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