Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1992-05-27
1994-09-06
Hill, Jr., Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436501, 436536, 436518, 435 71, 435 79, 435 792, G01N 33538
Patent
active
053447603
ABSTRACT:
Diagnostic/prognostic methods are provided for detecting and/or quantitating in the body fluids, preferably serum, of mammals carrying a malignant tumor burden, elevated levels of a portion of the epidermal growth factor receptor (EGFr) which comprises substantially the EGFr ectodomain having a molecular weight in the range of from about 90 kilodaltons (kd) to about 115 kd, preferably from about 95 kd to about 105 kd, and more preferably about 100 kd. Substantially pure compositions comprising said EGFr ectodoman protein and/or fragments thereof are disclosed as well as test kits for performing the disclosed assays.
REFERENCES:
patent: 4699877 (1987-10-01), Cline et al.
patent: 4933294 (1990-06-01), Waterfield et al.
patent: 4943533 (1990-07-01), Mendelsohn et al.
patent: 5221612 (1993-06-01), Zhau et al.
Ullrich et al., Nature, 309 (5967): 418-425 (May 31, 1984).
Gullick et al., Proc. R. Soc. Lond., B226: 127-134 (1985).
Adamson and Rees, Mol. Cell Biochem., 34: 129-152 (1981).
Thompson and Gill, Cancer Surveys 4(4): 768-788 (1985).
Fabricant et al., PNAS (USA), 74(2): 565-569 (1977).
Wrann and Fox, J. Biol. Chem., 254: 8083-8086 (1979).
Downward et al., Nature, 307(5951): 521-527 (1984).
Schreiber et al., PNAS (USA), 78: 7535-7539 (1981).
Waterfield et al., J. Cell Biochem., 20: 149-161 (1982).
Kawamoto et al., PNAS (USA), 80: 1337-1341 (1983).
Richert et al., J. Biol. Chem., 258: 8902-8907 (1983).
Bauknecht et al., Gynecologic Oncology, 29(2): 147-157 (Feb. 1988).
Gullick et al., Cancer Res. 46: 285-292 (1986).
Berger et al., J. Pathol. 152: 297-307 (1987).
Neal et al., Lancet, 1(8425): 366-368 (Feb. 16, 1985).
Fitzpatrick et al., Cancer Res., 44: 3448-3453 (1984).
Nicholson et al., Int. J. Cancer, 42: 36-41 (1988).
Nicholson et al., Lancet, 1(8631): 182-185 (Jan. 28, 1989).
Sainsbury et al., Lancet, 1(8547): 1398-1402 (Jun. 20, 1987).
Waterfield et al., Cell Biol. Internat'l Reports, 7(7): 535-537 (Jul. 1983).
Hapgood et al., PNAS (USA), 80(21): 6451-6455 (Nov. 1983).
Merlino et al., Science 229: 417-419 (Apr. 27, 1984).
Xu et al., Nature 309(5971): 806-810 (Jun. 1984).
Lin et al., Science, 224:843-848 (1984).
Gullick et al., Anal. Biochem. 141: 253-261 (1984).
Weber and Gill, Science, 224: 294 (1984).
Mayes and Waterfield, EMBO J., 3: 531-537 (1984).
Cooper et al., J. Virology, 48: 752-764 (1983).
Weber, Acta Endocrino Logica, 117 (Suppl. 287): 47 (No. 55) (1988).
Stoscheck and Carpenter, J. Cell Biol., 98: 1048-1053 (Mar. 1984).
Perez et al., Breast Cancer Res. and Treatment (4): 189-193 (1984).
Waterfield et al., Chemical Abstracts, 99(19): 156453e (p. 455) (Nov. 7, 1983).
Parker et al., J. Biol. Chem., 259(15): 9906-9912 (Aug. 10, 1984).
Libermann et al., Cancer Res. 44: 753-760 (1984).
Cohen et al., J. Biol. Chem., 257(3): 1523-1531 (Feb. 19, 1982).
Carlin and Knowles, PNAS (USA), 79: 5026-5030 (Aug. 1982).
Grimaux et al., Int. J. Cancer, 45: 255-262 (1990).
Humphrey et al., Can. Res. 48: 2231-2238 (Apr. 15, 1988).
Humphrey et al., PNAS (USA), 87: 4207-4211 (Jun. 1990).
Maiden et al., Can. Res. 48: 2711-2714 (May 15, 1988).
Smith et al., Cancer Res., 49: 5810-5815 (1989).
Hendler and Ozanne, J. Clin. Inves., 74: 647-651 (1984).
Xu et al., PNAS (USA), 81: 7308-7312 (1984).
Gullick and Waterfield, "Epidermal Growth Factor and Its Receptor," Chapter 1, pp. 15-34 in Ellis Horwood Series in Biomedicine: The Molecular Biology of Receptors. Techniques and Applications of Receptor Research (Stresburg ed.) (VCH Publishers Inc., N.Y.C., NY 1987).
Mol. & Cell Biol. 10(6): 2973-2987 (Jun. 1990) Petch et al., A Truncated, Secreted Form of the Epidermal Growth Factor Receptor is Encoded by an Alternatively Spliced . . . .
Crebbin Victoria A.
Hammond Susan L.
Harvey Jeanne P.
Liu Victor
McDonald Patricia A.
Ciba Corning Diagnostics Corp.
Hill Jr. Robert J.
Kruse Norman J.
Lauder Leona L.
Morgenstern Arthur S.
LandOfFree
Method of cancer detection does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of cancer detection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of cancer detection will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1329178