Method of biomolecule attachment to hydrophobic surfaces

Details Method of biomolecule attachment to hydrophobic surfaces Method of biomolecule attachment to hydrophobic surfaces

1991-03-19

1993-11-02

Prebilic, Paul

Prosthesis (i.e., artificial body members), parts thereof, or ai

Miscellaneous

604266, 427 2, 623901, 435181, 436501, A61F 254

Patent

active

052580415

ABSTRACT:
A method for attaching a biomolecule to a support having a hydrophobic surface, involving the use of a long chain chemical spacer having a hydrophobic guiding group capable of becoming embedded in the surface, and the biomolecule being covalently bound to the spacer at its opposite end.

REFERENCES:
patent: 3808113 (1974-04-01), Okamura et al.
patent: 3826678 (1974-07-01), Hoffman et al.
patent: 3888833 (1975-06-01), Lednicer et al.
patent: 3955012 (1975-05-01), Okamura et al.
patent: 3959078 (1976-05-01), Guire
patent: 4007089 (1977-02-01), Smith, III
patent: 4160698 (1979-07-01), Miyairi et al.
patent: 4240163 (1980-12-01), Galin
patent: 4273873 (1981-06-01), Sugitach et al.
patent: 4307071 (1977-08-01), Murray et al.
patent: 4311573 (1982-01-01), Mayhan et al.
patent: 4326532 (1982-04-01), Hammar
patent: 4378224 (1983-03-01), Nimni et al.
patent: 4378435 (1983-03-01), Takagi et al.
patent: 4419444 (1983-12-01), Quash
patent: 4434150 (1984-02-01), Azad et al.
patent: 4451568 (1984-05-01), Schneider et al.
patent: 4500676 (1985-02-01), Balazsa et al.
patent: 4526714 (1985-07-01), Feijen et al.
patent: 4526909 (1985-07-01), Urist
patent: 4530974 (1985-07-01), Munro et al.
patent: 4536179 (1985-08-01), Anderson et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4589964 (1986-05-01), Mayhan et al.
patent: 4595632 (1986-06-01), Mayhan et al.
patent: 4597999 (1986-07-01), Lingwood
patent: 4605413 (1986-08-01), Urry et al.
patent: 4657820 (1987-04-01), Halpern et al.
patent: 4663233 (1987-05-01), Beavers
patent: 4687808 (1987-08-01), Jarrett et al.
patent: 4715858 (1987-12-01), Lindstrom
patent: 4722906 (1988-02-01), Guire
patent: 4726122 (1987-12-01), Scheefers
patent: 4743258 (1988-05-01), Ikada et al.
patent: 4828563 (1989-05-01), Muller-Lierheim
patent: 4973493 (1990-11-01), Guire
patent: 4979959 (1990-12-01), Guire
patent: 5002582 (1991-03-01), Guire et al.
patent: 5002883 (1991-03-01), Bieniarz et al.
Guire et al, "Stepwise-Crosslinking Reagents for Photocoupling of Enzymes and Lectins to Mammalian Cells", Glycoconjugate Research, vol. II (1979) pp. 1051-1054.
CRC Handbook of Chemistry and Physics, 64th Ed., 1983-1984, p. 171.
Ebert, et al., "The Anticoagulant Activity of Derivatized and Immobilized Heparins", Eds., Am. Chem. Soc., (1982), pp. 161-176.
Larsson, et al., "Covalent Binding of Proteins to Grafted Plastic Surfaces Suitable for Immunoassays", J. Immuno. Methods, (1987), pp. 129-135.
Engbers, et al., "An In Vitro Study of Adhesion of Blood Platelets Into Vascular Catheters", J. Biom. Mat., Res., vol. 21, (1987), pp. 613-627.
Evangelista, et al., "Coating of Two Polyether-polyurethanes and Polyethylene with Heparin-poly (vinyl alcohol) Hydrogel", Biomaterials, vol. 7, May 1986, pp. 206-211.
Heyman, et al., "Heparinized Polyurethanes: In Vitro and In Vivo Studies", J. Biom. Mat. Res., vol. 19, (1985), pp. 419-436.
Palatianos; et al., "Extracorporeal Left Ventricular Assistance with Prostacyclin and Heparinized Centrifugal Pump", The Annals of Thorasic Surgery, vol. 35, No. 5, (1983), pp. 504,515.
Larm, et al., "A New Non-Thrombogenic Surface Prepared by Selective Colvanet Binding of Heparin Via a Modified Reducing Terminal Residue", Bioamat. Med. Dev., Art. Org. 11, (2&3), (1983), pp. 161-173.
Hoffman, et al., "A New Method for Covalently Coupling of Heparin and Other Glycosaminoglycans to Substances Containing Primary Amino Groups", vol. 117, Carbohydrate Research, (1983), pp. 328-331.
Bennegard, et al., "Material Thrombogenicity in Central Venous Catheterization", Acta. Anaesth. Scand., (1982), vol. 26, pp. 112-120.
Nillson, et al., "Polarographic p.sup.o 2 Senors with Heparinized Membranes for In Vitro and Continuous Im Vivo Registration", Scan. J. Clin. Lab. Invest., vol. 41, (1981) pp. 557-563.
Kim, et al., Surface Modification of Polymers for Improved Blood Compatibility, CRC Critical Reviews in Biocompatibility, vol. 1, Issue 3, pp. 229-260.
Katzenellenbagen, et al., Biochem., 13(14):2986-2994 (1974).
Gormain, et al., "Transglutaminase Amine Substrates", J. Biol. Chem. 255, 1175-1180 (1980).
Guire, "Photochemical Immobilization of Enzymes and Other Biochemicals", Methods in Enzymology, vol. XLIV, (1976), pp. 280-288, (ed. Klaus Mosbach).

Affiliated with

Also associated with

Rating

Method of biomolecule attachment to hydrophobic surfaces does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of biomolecule attachment to hydrophobic surfaces, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of biomolecule attachment to hydrophobic surfaces will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1755171